Fields »
ABOUT
HELP
BLOG
BMF

CANCER ATLAS

Gene description

 Bcl2 modifying factor

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA010120

GENE INFORMATION

Gene name

 BMF (HGNC Symbol)

Synonyms

 FLJ00065

Description

 Bcl2 modifying factor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q15.1

Chromosome location (bp)

 40087890 - 40108892

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104081 (version 83.38)

Entrez gene

 90427

UniProt

 Q96LC9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96LC9

Antibodypedia

 BMF antibodies

PROTEIN BROWSER
BMF-001
BMF-002
BMF-003
BMF-004
BMF-005
BMF-006
BMF-007
BMF-009
BMF-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BMF-001
ENSP00000346697
ENST00000354670
Q96LC9 [Direct mapping]
Bcl-2-modifying factor
Show all
Predicted intracellular proteins
Show all
GO:0001669 [acrosomal vesicle]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0012501 [programmed cell death]
GO:0015629 [actin cytoskeleton]
GO:0016459 [myosin complex]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0043276 [anoikis]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2001234 [negative regulation of apoptotic signaling pathway]
GO:2001235 [positive regulation of apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 184 aa
20.5 kDa 		No 0
BMF-002
ENSP00000396511
ENST00000431415
Q96LC9 [Direct mapping]
Bcl-2-modifying factor
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0012501 [programmed cell death]
GO:0016459 [myosin complex]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0043276 [anoikis]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 163 aa
18 kDa 		No 0
BMF-003
ENSP00000453919
ENST00000559701
Q96LC9 [Direct mapping]
Bcl-2-modifying factor
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0012501 [programmed cell death]
GO:0016459 [myosin complex]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0043276 [anoikis]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 129 aa
14.1 kDa 		No 0
BMF-004
ENSP00000380703
ENST00000397573
Q96LC9 [Direct mapping]
Bcl-2-modifying factor
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0012501 [programmed cell death]
GO:0016459 [myosin complex]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0043276 [anoikis]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 184 aa
20.5 kDa 		No 0
BMF-005
ENSP00000453522
ENST00000561282
Q96LC9 [Direct mapping]
Bcl-2-modifying factor
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0012501 [programmed cell death]
GO:0016459 [myosin complex]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0043276 [anoikis]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 184 aa
20.5 kDa 		No 0
BMF-006
ENSP00000453913
ENST00000558774
Q96LC9 [Direct mapping]
Bcl-2-modifying factor
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0012501 [programmed cell death]
GO:0016459 [myosin complex]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0043276 [anoikis]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 129 aa
14.1 kDa 		No 0
BMF-007
ENSP00000454142
ENST00000557870
H0YNT3 [Direct mapping]
Bcl-2-modifying factor
Show all
Predicted intracellular proteins
Show all
GO:0006915 [apoptotic process]
Show all
 61 aa
6.7 kDa 		No 0
BMF-009
ENSP00000452660
ENST00000560430
H0YK50 [Direct mapping]
Bcl-2-modifying factor
Show all
Predicted intracellular proteins
Show all
 13 aa
1.5 kDa 		No 0
BMF-010
ENSP00000453892
ENST00000561360
Q96LC9 [Direct mapping]
Bcl-2-modifying factor
Show all
Predicted intracellular proteins
Show all
GO:0005515 [protein binding]
GO:0005741 [mitochondrial outer membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006915 [apoptotic process]
GO:0012501 [programmed cell death]
GO:0016459 [myosin complex]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0043276 [anoikis]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 184 aa
20.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.