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SCG3

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GENERAL INFORMATION

Gene name

 SCG3

Gene description

 Secretogranin III

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to vesicles.

RNA cell category

 Group enriched (SCLC-21H, SH-SY5Y, NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (validated)

DATA RELIABILITY

Reliability score

 Validated based on 1 antibody.
HPA053715
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (SCLC-21H, SH-SY5Y, NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to vesicles.

Main location

 Vesicles (validated)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA053715 HEK 293 No staining    
HPA053715 SH-SY5Y Vesicles
HPA053715 U-2 OS Vesicles

GENE INFORMATION

Gene name

 SCG3 (HGNC Symbol)

Synonyms

 FLJ90833, SgIII

Description

 Secretogranin III (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Granins may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones; however, the function of this protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 51681353 - 51721031

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104112 (version 83.38)

Entrez gene

 29106

UniProt

 Q8WXD2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WXD2

Antibodypedia

 SCG3 antibodies

PROTEIN BROWSER
SCG3-001
SCG3-002
SCG3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SCG3-001
ENSP00000220478
ENST00000220478
Q8WXD2 [Direct mapping]
Secretogranin-3
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005576 [extracellular region]
GO:0007596 [blood coagulation]
GO:0030168 [platelet activation]
GO:0030658 [transport vesicle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034774 [secretory granule lumen]
GO:0044822 [poly(A) RNA binding]
Show all
 468 aa
53 kDa 		Yes 0
SCG3-002
ENSP00000445205
ENST00000542355
Q8WXD2 [Direct mapping]
Secretogranin-3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002576 [platelet degranulation]
GO:0005576 [extracellular region]
GO:0007596 [blood coagulation]
GO:0030168 [platelet activation]
GO:0030658 [transport vesicle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0034774 [secretory granule lumen]
GO:0044822 [poly(A) RNA binding]
Show all
 236 aa
26.9 kDa 		No 0
SCG3-003
ENSP00000452745
ENST00000558709
H0YKC2 [Direct mapping]
Secretogranin-3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 57 aa
6.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.