Cell atlas - CSPP1 - The Human Protein Atlas

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CSPP1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Microtubule organizing center

Human cell
	Centrosome

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GENERAL INFORMATION
Gene name	CSPP1
Gene description	Centrosome and spindle pole associated protein 1
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubule organizing center.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubule organizing center (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA056174
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubule organizing center.

Main location

Microtubule organizing center (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056174	A-431	Microtubule organizing center
	HPA056174	HEK 293	Microtubule organizing center
	HPA056174	HEK 293	Aggresome
	HPA056174	U-2 OS	Microtubule organizing center

GENE INFORMATION
Gene name	CSPP1 (HGNC Symbol)
Synonyms	CSPP, FLJ22490, JBTS21
Description	Centrosome and spindle pole associated protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Chromosome	8
Cytoband
Chromosome location (bp)	67062426 - 67196263
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104218 (version 83.38)
Entrez gene	79848
UniProt	Q1MSJ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q1MSJ5
Antibodypedia	CSPP1 antibodies

PROTEIN BROWSER

CSPP1-001	CSPP1-003	CSPP1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSPP1-001 ENSP00000262210 ENST00000262210	Q1MSJ5 [Direct mapping] Centrosome and spindle pole-associated protein 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0032467 [positive regulation of cytokinesis] GO:0051781 [positive regulation of cell division] Show all	1221 aa 141.8 kDa	No	0
CSPP1-003 ENSP00000430092 ENST00000519668	Q1MSJ5 [Direct mapping] Centrosome and spindle pole-associated protein 1 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005819 [spindle] GO:0005874 [microtubule] GO:0032467 [positive regulation of cytokinesis] GO:0051781 [positive regulation of cell division] Show all	876 aa 101.6 kDa	No	0
CSPP1-005 ENSP00000429546 ENST00000521919	E5RI67 [Direct mapping] Centrosome and spindle pole-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005813 [centrosome] GO:0005874 [microtubule] GO:0032467 [positive regulation of cytokinesis] Show all	154 aa 17.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.