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Cases of gliomas, breast, renal, pancreatic and liver cancers showed nuclear and additional cytoplasmic positivity. Remaining cancer cells were negative.
Several cancer tissues including gastric, pancreatic and cervical cancers, displayed strong cytoplasmic staining in a few cases. Cancer cells in general were negative.
GENE INFORMATION
Gene name
CA2 (HGNC Symbol)
Synonyms
CA-II, CAII, Car2
Description
Carbonic anhydrase II (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is one of several isozymes of carbonic anhydrase, which catalyzes reversible hydration of carbon dioxide. Defects in this enzyme are associated with osteopetrosis and renal tubular acidosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Enzymes ENZYME proteins Lyases Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)