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TRPA1

GENERAL INFORMATION

Gene name

 TRPA1

Gene description

 Transient receptor potential cation channel, subfamily A, member 1

Protein class

 Disease related genes
FDA approved drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (urinary bladder)
GTEx:Group enriched (urinary bladder, small intestine, stomach, colon)
FANTOM5:Tissue enhanced (small intestine, colon)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in gastrointestinal tract, gall bladder and urinary bladder.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA026630
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Oral mucosa

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (urinary bladder, small intestine, stomach, colon)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine, colon)

GENE INFORMATION

Gene name

 TRPA1 (HGNC Symbol)

Synonyms

 ANKTM1

Description

 Transient receptor potential cation channel, subfamily A, member 1 (HGNC Symbol)

Entrez gene summary

 The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q21.11

Chromosome location (bp)

 72019917 - 72075617

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104321 (version 83.38)

Entrez gene

 8989

UniProt

 O75762 (UniProt - Evidence at protein level)

neXtProt

 NX_O75762

Antibodypedia

 TRPA1 antibodies

PROTEIN BROWSER
TRPA1-001
TRPA1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPA1-001
ENSP00000262209
ENST00000262209
O75762 [Direct mapping]
Transient receptor potential cation channel subfamily A member 1
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005218 [intracellular ligand-gated calcium channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0007166 [cell surface receptor signaling pathway]
GO:0009409 [response to cold]
GO:0010033 [response to organic substance]
GO:0014070 [response to organic cyclic compound]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0019233 [sensory perception of pain]
GO:0032421 [stereocilium bundle]
GO:0034220 [ion transmembrane transport]
GO:0042493 [response to drug]
GO:0042542 [response to hydrogen peroxide]
GO:0048265 [response to pain]
GO:0050955 [thermoception]
GO:0050966 [detection of mechanical stimulus involved in sensory perception of pain]
GO:0050968 [detection of chemical stimulus involved in sensory perception of pain]
GO:0051289 [protein homotetramerization]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0097604 [temperature-gated cation channel activity]
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 1119 aa
127.5 kDa 		No 6
TRPA1-002
ENSP00000428151
ENST00000523582
H0YAW0 [Direct mapping]
Transient receptor potential cation channel subfamily A member 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005515 [protein binding]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
Show all
 916 aa
103.5 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.