Cell atlas - IMPAD1 - The Human Protein Atlas

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IMPAD1

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TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus
	Nucleus

Human cell
	Cytosol
	Golgi Apparatus
	Nucleoplasm

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GENERAL INFORMATION
Gene name	IMPAD1
Gene description	Inositol monophosphatase domain containing 1
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the nucleus & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)
Additional location	In addition localized to the Nucleus (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA009411
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the nucleus & cytosol.

Main location

Golgi apparatus (supported)

Additional location

Nucleus (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA009411	A-431	Nucleus
	HPA009411	A-431	Golgi apparatus
	HPA009411	U-2 OS	Nucleus
			Golgi apparatus
			Cytosol
	HPA009411	U-251 MG	Nucleus
			Nuclear bodies
			Golgi apparatus

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA009411	U-2 OS	Image	Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. IMPAD1 localizes to the Golgi apparatus, but not to the cis-Golgi compartment.

GENE INFORMATION
Gene name	IMPAD1 (HGNC Symbol)
Synonyms	FLJ20421, gPAPP, IMPA3
Description	Inositol monophosphatase domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. [provided by RefSeq, Dec 2011]
Chromosome	8
Cytoband	q12.1
Chromosome location (bp)	56957933 - 56993844
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104331 (version 83.38)
Entrez gene	54928
UniProt	Q9NX62 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NX62
Antibodypedia	IMPAD1 antibodies

PROTEIN BROWSER

IMPAD1-001	IMPAD1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IMPAD1-001 ENSP00000262644 ENST00000262644	Q9NX62 [Direct mapping] Inositol monophosphatase 3 A0A024R7W0 [Target identity:100%; Query identity:100%] Inositol monophosphatase domain containing 1, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0001501 [skeletal system development] GO:0001958 [endochondral ossification] GO:0002063 [chondrocyte development] GO:0005794 [Golgi apparatus] GO:0006021 [inositol biosynthetic process] GO:0008254 [3'-nucleotidase activity] GO:0008441 [3'(2'),5'-bisphosphate nucleotidase activity] GO:0008934 [inositol monophosphate 1-phosphatase activity] GO:0009791 [post-embryonic development] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0030204 [chondroitin sulfate metabolic process] GO:0042733 [embryonic digit morphogenesis] GO:0046854 [phosphatidylinositol phosphorylation] GO:0052832 [inositol monophosphate 3-phosphatase activity] GO:0052833 [inositol monophosphate 4-phosphatase activity] Show all	359 aa 38.7 kDa	No	1
IMPAD1-002 ENSP00000430185 ENST00000517461	H0YBS3 [Direct mapping] Inositol monophosphatase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046854 [phosphatidylinositol phosphorylation] Show all	82 aa 9.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.