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Cancer tissues displayed weak to moderate cytoplasmic staining in most cases.
GENE INFORMATION
Gene name
SFRP1 (HGNC Symbol)
Synonyms
FRP, FRP-1, SARP2
Description
Secreted frizzled-related protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]
Q6ZSL4 [Direct mapping] Secreted frizzled-related protein 1; Secreted frizzled-related protein 1, isoform CRA_a; cDNA FLJ45402 fis, clone BRHIP3029409, moderately similar to Homo sapiens secreted frizzled-related protein 1 (SFRP1)
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)