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JPH1

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GENERAL INFORMATION

Gene name

 JPH1

Gene description

 Junctophilin 1

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus.

RNA cell category

 Cell line enhanced (SK-BR-3, T-47d)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Mouse

 Localized to the Nucleus, Nucleoli in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA008996 , HPA009413
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SK-BR-3, T-47d)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA008996 A-431 Nucleoplasm
HPA008996 U-2 OS Nucleoplasm
HPA008996 U-251 MG Nucleoplasm
HPA009413 A-431 Nucleus
HPA009413 U-2 OS Nucleus
HPA009413 U-251 MG Nucleus

MOUSE CELLS

Main location

 Nucleus, Nucleoli

Additional location

 Focal adhesion sites

Mouse gene

 ENSMUSG00000042686 (version 83)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA008996 NIH 3T3 Nucleus
Nucleoli
Focal adhesion sites

GENE INFORMATION

Gene name

 JPH1 (HGNC Symbol)

Synonyms

 JP-1

Description

 Junctophilin 1 (HGNC Symbol)

Entrez gene summary

 Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q21.11

Chromosome location (bp)

 74234700 - 74321328

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104369 (version 83.38)

Entrez gene

 56704

UniProt

 Q9HDC5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HDC5

Antibodypedia

 JPH1 antibodies

PROTEIN BROWSER
JPH1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
JPH1-001
ENSP00000344488
ENST00000342232
Q9HDC5 [Direct mapping]
Junctophilin-1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0007517 [muscle organ development]
GO:0008307 [structural constituent of muscle]
GO:0014701 [junctional sarcoplasmic reticulum membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0030314 [junctional membrane complex]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060402 [calcium ion transport into cytosol]
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 661 aa
71.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.