Expression of DKK4 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Dickkopf WNT signaling pathway inhibitor 4

Protein class

Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA052916

GENE INFORMATION
Gene name	DKK4
Synonyms
Description	Dickkopf WNT signaling pathway inhibitor 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	p11.21
Chromosome location (bp)	42374068 - 42377232
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104371 (version 83.38)
Entrez gene	27121
UniProt	Q9UBT3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBT3
Antibodypedia	DKK4 antibodies

PROTEIN BROWSER

DKK4-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DKK4-001 ENSP00000220812 ENST00000220812	Q9UBT3 [Direct mapping] Dickkopf-related protein 4 Dickkopf-related protein 4 short form Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005575 [cellular_component] GO:0005576 [extracellular region] GO:0007275 [multicellular organismal development] GO:0016055 [Wnt signaling pathway] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0061170 [negative regulation of hair follicle placode formation] Show all	224 aa 24.9 kDa	Yes	0