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STK3

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GENERAL INFORMATION

Gene name

 STK3

Gene description

 Serine/threonine kinase 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol. In addition localized to the intermediate filaments & rods & rings.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

Additional location

 In addition localized to the Intermediate filaments (approved), Rods & Rings (approved)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA007120
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol. In addition localized to the intermediate filaments & rods & rings.

Main location

 Cytosol (approved)

Additional location

 Intermediate filaments (approved), Rods & Rings (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA007120 A-431 Cytosol
Rods & Rings
HPA007120 HaCaT Intermediate filaments Intensity
HPA007120 U-2 OS Rods & Rings

GENE INFORMATION

Gene name

 STK3 (HGNC Symbol)

Synonyms

 KRS1, MST2

Description

 Serine/threonine kinase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 8

Cytoband

 q22.2

Chromosome location (bp)

 98401403 - 98942827

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104375 (version 83.38)

Entrez gene

 6788

UniProt

 Q13188 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13188

Antibodypedia

 STK3 antibodies

PROTEIN BROWSER
STK3-001
STK3-002
STK3-005
STK3-016
STK3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STK3-001
ENSP00000390500
ENST00000419617
Q13188 [Direct mapping]
Serine/threonine-protein kinase 3 Serine/threonine-protein kinase 3 36kDa subunit Serine/threonine-protein kinase 3 20kDa subunit
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000287 [magnesium ion binding]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032092 [positive regulation of protein binding]
GO:0035329 [hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0046983 [protein dimerization activity]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
Show all
 491 aa
56.3 kDa 		No 0
STK3-002
ENSP00000429744
ENST00000523601
Q13188 [Direct mapping]
Serine/threonine-protein kinase 3 Serine/threonine-protein kinase 3 36kDa subunit Serine/threonine-protein kinase 3 20kDa subunit
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000287 [magnesium ion binding]
GO:0001841 [neural tube formation]
GO:0003157 [endocardium development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0007417 [central nervous system development]
GO:0008285 [negative regulation of cell proliferation]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032092 [positive regulation of protein binding]
GO:0035329 [hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0046330 [positive regulation of JNK cascade]
GO:0046621 [negative regulation of organ growth]
GO:0046983 [protein dimerization activity]
GO:0050821 [protein stabilization]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060215 [primitive hemopoiesis]
GO:0060706 [cell differentiation involved in embryonic placenta development]
GO:0060800 [regulation of cell differentiation involved in embryonic placenta development]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097284 [hepatocyte apoptotic process]
GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]
Show all
 519 aa
59.5 kDa 		No 0
STK3-005
ENSP00000428014
ENST00000518165
E5RFQ9 [Direct mapping]
Serine/threonine-protein kinase 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 229 aa
26.1 kDa 		No 0
STK3-016
ENSP00000428295
ENST00000519420
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 1 aa
0.1 kDa 		No 0
STK3-201
ENSP00000482260
ENST00000617590
A0A087WZ06 [Direct mapping]
Serine/threonine-protein kinase 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 380 aa
44 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.