Expression of GDAP1 in cancer - Summary

CANCER ATLAS

Gene description

Ganglioside induced differentiation associated protein 1

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA014266	HPA024334

GENE INFORMATION
Gene name	GDAP1 (HGNC Symbol)
Synonyms	CMT2K, CMT4, CMT4A
Description	Ganglioside induced differentiation associated protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ganglioside-induced differentiation-associated protein family, which may play a role in a signal transduction pathway during neuronal development. Mutations in this gene have been associated with various forms of Charcot-Marie-Tooth Disease and neuropathy. Two transcript variants encoding different isoforms and a noncoding variant have been identified for this gene. [provided by RefSeq, Feb 2012]
Chromosome	8
Cytoband	q21.11
Chromosome location (bp)	74321130 - 74488872
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104381 (version 83.38)
Entrez gene	54332
UniProt	Q8TB36 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TB36
Antibodypedia	GDAP1 antibodies

PROTEIN BROWSER

GDAP1-001	GDAP1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GDAP1-001 ENSP00000220822 ENST00000220822	Q8TB36 [Direct mapping] Ganglioside-induced differentiation-associated protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000266 [mitochondrial fission] GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006626 [protein targeting to mitochondrion] GO:0006749 [glutathione metabolic process] GO:0008053 [mitochondrial fusion] GO:0016020 [membrane] GO:0031307 [integral component of mitochondrial outer membrane] GO:0032526 [response to retinoic acid] Show all	358 aa 41.3 kDa	No	2
GDAP1-002 ENSP00000417006 ENST00000434412	Q8TB36 [Direct mapping] Ganglioside-induced differentiation-associated protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000266 [mitochondrial fission] GO:0004364 [glutathione transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006626 [protein targeting to mitochondrion] GO:0006749 [glutathione metabolic process] GO:0008053 [mitochondrial fusion] GO:0016020 [membrane] GO:0031307 [integral component of mitochondrial outer membrane] Show all	290 aa 33.5 kDa	No	2