Expression of NDRG1 in cancer - Summary

CANCER ATLAS

Gene description

N-myc downstream regulated 1

Protein class

Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA006881

GENE INFORMATION
Gene name	NDRG1 (HGNC Symbol)
Synonyms	CAP43, DRG1, NDR1, RTP, TDD5
Description	N-myc downstream regulated 1 (HGNC Symbol)
Entrez gene summary	This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Chromosome	8
Cytoband	q24.22
Chromosome location (bp)	133237171 - 133302022
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104419 (version 83.38)
Entrez gene	10397
UniProt	Q92597 (UniProt - Evidence at protein level)
neXtProt	NX_Q92597
Antibodypedia	NDRG1 antibodies

PROTEIN BROWSER

NDRG1-001	NDRG1-002	NDRG1-003	NDRG1-004	NDRG1-010	NDRG1-011	NDRG1-012	NDRG1-013	NDRG1-014	NDRG1-015	NDRG1-016	NDRG1-017	NDRG1-020	NDRG1-030	NDRG1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDRG1-001 ENSP00000404854 ENST00000414097	Q92597 [Direct mapping] Protein NDRG1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0008017 [microtubule binding] GO:0008285 [negative regulation of cell proliferation] GO:0010038 [response to metal ion] GO:0015630 [microtubule cytoskeleton] GO:0017137 [Rab GTPase binding] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0043015 [gamma-tubulin binding] GO:0043209 [myelin sheath] GO:0045296 [cadherin binding] GO:0045576 [mast cell activation] GO:0048471 [perinuclear region of cytoplasm] GO:0055038 [recycling endosome membrane] GO:0070062 [extracellular exosome] GO:0071456 [cellular response to hypoxia] GO:0090232 [positive regulation of spindle checkpoint] Show all	394 aa 42.8 kDa	No	0
NDRG1-002 ENSP00000319977 ENST00000323851	Q92597 [Direct mapping] Protein NDRG1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0008017 [microtubule binding] GO:0010038 [response to metal ion] GO:0015630 [microtubule cytoskeleton] GO:0017137 [Rab GTPase binding] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0043015 [gamma-tubulin binding] GO:0045296 [cadherin binding] GO:0048471 [perinuclear region of cytoplasm] GO:0055038 [recycling endosome membrane] GO:0070062 [extracellular exosome] GO:0071456 [cellular response to hypoxia] GO:0090232 [positive regulation of spindle checkpoint] Show all	394 aa 42.8 kDa	No	0
NDRG1-003 ENSP00000429007 ENST00000518176	E7ESM1 [Direct mapping] Protein NDRG1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	141 aa 15 kDa	No	0
NDRG1-004 ENSP00000427894 ENST00000522476	Q92597 [Direct mapping] Protein NDRG1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0008017 [microtubule binding] GO:0010038 [response to metal ion] GO:0015630 [microtubule cytoskeleton] GO:0017137 [Rab GTPase binding] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0043015 [gamma-tubulin binding] GO:0045296 [cadherin binding] GO:0048471 [perinuclear region of cytoplasm] GO:0055038 [recycling endosome membrane] GO:0070062 [extracellular exosome] GO:0071456 [cellular response to hypoxia] GO:0090232 [positive regulation of spindle checkpoint] Show all	328 aa 35.5 kDa	No	0
NDRG1-010 ENSP00000428345 ENST00000520230	E5RIV1 [Direct mapping] Protein NDRG1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	193 aa 21.2 kDa	No	0
NDRG1-011 ENSP00000429840 ENST00000520943	E5RH82 [Direct mapping] Protein NDRG1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	157 aa 17.1 kDa	No	0
NDRG1-012 ENSP00000429994 ENST00000519228	E5RGM5 [Direct mapping] Protein NDRG1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	165 aa 18.2 kDa	No	0
NDRG1-013 ENSP00000428384 ENST00000522890	E5RIR1 [Direct mapping] Protein NDRG1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	158 aa 17.4 kDa	No	0
NDRG1-014 ENSP00000429272 ENST00000519580	E5RIR1 [Direct mapping] Protein NDRG1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	158 aa 17.4 kDa	No	0
NDRG1-015 ENSP00000428991 ENST00000522738	E5RK17 [Direct mapping] Protein NDRG1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	167 aa 18.5 kDa	No	0
NDRG1-016 ENSP00000429524 ENST00000521544	E5RI76 [Direct mapping] Protein NDRG1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	133 aa 14.8 kDa	No	0
NDRG1-017 ENSP00000428802 ENST00000518480	E5RG99 [Direct mapping] Protein NDRG1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	100 aa 11 kDa	No	0
NDRG1-020 ENSP00000430171 ENST00000523892	E5RGG6 [Direct mapping] Protein NDRG1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	43 aa 4.8 kDa	No	0
NDRG1-030 ENSP00000431057 ENST00000518066	E5RJY1 [Direct mapping] Protein NDRG1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0032287 [peripheral nervous system myelin maintenance] GO:0042127 [regulation of cell proliferation] GO:0045576 [mast cell activation] Show all	103 aa 11 kDa	No	0
NDRG1-201 ENSP00000437443 ENST00000537882	Q92597 [Direct mapping] Protein NDRG1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005874 [microtubule] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0008017 [microtubule binding] GO:0010038 [response to metal ion] GO:0015630 [microtubule cytoskeleton] GO:0017137 [Rab GTPase binding] GO:0030330 [DNA damage response, signal transduction by p53 class mediator] GO:0043015 [gamma-tubulin binding] GO:0045296 [cadherin binding] GO:0048471 [perinuclear region of cytoplasm] GO:0055038 [recycling endosome membrane] GO:0070062 [extracellular exosome] GO:0071456 [cellular response to hypoxia] GO:0090232 [positive regulation of spindle checkpoint] Show all	313 aa 33.6 kDa	No	0