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STMN2

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GENERAL INFORMATION

Gene name

 STMN2

Gene description

 Stathmin 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to vesicles. In addition localized to the endoplasmic reticulum.

RNA cell category

 Cell line enriched (SH-SY5Y)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (approved)

Additional location

 In addition localized to the Endoplasmic reticulum (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA026922
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (SH-SY5Y)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to vesicles. In addition localized to the endoplasmic reticulum.

Main location

 Vesicles (approved)

Additional location

 Endoplasmic reticulum (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA026922 BJ Endoplasmic reticulum
Vesicles
HPA026922 U-2 OS Vesicles
HPA026922 U-251 MG Vesicles

GENE INFORMATION

Gene name

 STMN2 (HGNC Symbol)

Synonyms

 SCG10, SCGN10

Description

 Stathmin 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Nov 2010]

Chromosome

 8

Cytoband

 q21.13

Chromosome location (bp)

 79610814 - 79666175

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104435 (version 83.38)

Entrez gene

 11075

UniProt

 Q93045 (UniProt - Evidence at protein level)

neXtProt

 NX_Q93045

Antibodypedia

 STMN2 antibodies

PROTEIN BROWSER
STMN2-001
STMN2-007
STMN2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STMN2-001
ENSP00000220876
ENST00000220876
Q93045 [Direct mapping]
Stathmin-2
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0007019 [microtubule depolymerization]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031175 [neuron projection development]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:1990090 [cellular response to nerve growth factor stimulus]
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 179 aa
20.8 kDa 		No 0
STMN2-007
ENSP00000430102
ENST00000518491
E5RGX5 [Direct mapping]
Stathmin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007019 [microtubule depolymerization]
GO:0015631 [tubulin binding]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031175 [neuron projection development]
Show all
 168 aa
19.6 kDa 		No 0
STMN2-008
ENSP00000429243
ENST00000518111
Q93045 [Direct mapping]
Stathmin-2
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0007019 [microtubule depolymerization]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0010976 [positive regulation of neuron projection development]
GO:0010977 [negative regulation of neuron projection development]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030027 [lamellipodium]
GO:0030424 [axon]
GO:0030426 [growth cone]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031115 [negative regulation of microtubule polymerization]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031175 [neuron projection development]
GO:0031982 [vesicle]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
 187 aa
21.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.