Tissue expression of UBR5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	UBR5
Gene description	Ubiquitin protein ligase E3 component n-recognin 5
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	UBR5 (HGNC Symbol)
Synonyms	DD5, EDD, EDD1, HYD, KIAA0896
Description	Ubiquitin protein ligase E3 component n-recognin 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q22.3
Chromosome location (bp)	102253012 - 102412841
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104517 (version 83.38)
Entrez gene	51366
UniProt	O95071 (UniProt - Evidence at protein level)
neXtProt	NX_O95071
Antibodypedia	UBR5 antibodies

PROTEIN BROWSER

UBR5-001	UBR5-002	UBR5-003	UBR5-004	UBR5-008	UBR5-009	UBR5-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBR5-001 ENSP00000429084 ENST00000520539	O95071 [Direct mapping] E3 ubiquitin-protein ligase UBR5 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016874 [ligase activity] GO:0033160 [positive regulation of protein import into nucleus, translocation] GO:0034450 [ubiquitin-ubiquitin ligase activity] GO:0035413 [positive regulation of catenin import into nucleus] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043130 [ubiquitin binding] GO:0050847 [progesterone receptor signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1901315 [negative regulation of histone H2A K63-linked ubiquitination] GO:2000780 [negative regulation of double-strand break repair] Show all	2799 aa 309.4 kDa	No	0
UBR5-002 ENSP00000220959 ENST00000220959	O95071 [Direct mapping] E3 ubiquitin-protein ligase UBR5 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006281 [DNA repair] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0016874 [ligase activity] GO:0033160 [positive regulation of protein import into nucleus, translocation] GO:0034450 [ubiquitin-ubiquitin ligase activity] GO:0035413 [positive regulation of catenin import into nucleus] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043130 [ubiquitin binding] GO:0050847 [progesterone receptor signaling pathway] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1901315 [negative regulation of histone H2A K63-linked ubiquitination] GO:2000780 [negative regulation of double-strand break repair] Show all	2798 aa 309.2 kDa	No	0
UBR5-003 ENSP00000427819 ENST00000521922	E7EMW7 [Direct mapping] E3 ubiquitin-protein ligase UBR5 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008270 [zinc ion binding] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0043130 [ubiquitin binding] Show all	2792 aa 308.6 kDa	No	0
UBR5-004 ENSP00000428693 ENST00000518205	E7ET84 [Direct mapping] E3 ubiquitin-protein ligase UBR5 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] Show all	527 aa 59.7 kDa	No	0
UBR5-008 ENSP00000428138 ENST00000519365	H0YAV7 [Direct mapping] E3 ubiquitin-protein ligase UBR5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		201 aa 21.6 kDa	No	0
UBR5-009 ENSP00000429127 ENST00000520898	H0YBB4 [Direct mapping] E3 ubiquitin-protein ligase UBR5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		195 aa 20.6 kDa	No	0
UBR5-013 ENSP00000428062 ENST00000521566	E5RFK7 [Direct mapping] E3 ubiquitin-protein ligase UBR5 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		166 aa 19.2 kDa	No	0