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Most cancer cells displayed weak to moderate cytoplasmic and membranous positivity. Several cases of colorectal, testicular, breast, ovarian and endometrial cancer were strongly stained. Several cases of lymphomas, skin and renal cancer were negative.
Cancer tissues displayed moderate cytoplasmic staining with additional membranous positivity in several cases. Majority of the cases of colorectal, thyroid and endometrial cancers along with few cases of ovarian, urothelial and liver cancers were strongly stained. Gliomas, lymphomas and several cases of melanomas, lung and skin cancers were weakly stained or negative.
GENE INFORMATION
Gene name
INTS10 (HGNC Symbol)
Synonyms
C8orf35, FLJ10569, INT10
Description
Integrator complex subunit 10 (HGNC Symbol)
Entrez gene summary
INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
