Cell atlas - SLC39A14 - The Human Protein Atlas

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SLC39A14

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Golgi apparatus
	Plasma membrane

Human cell
	Endoplasmic Reticulum
	Golgi Apparatus
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SLC39A14
Gene description	Solute carrier family 39 (zinc transporter), member 14
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane, endoplasmic reticulum & the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (approved), Golgi apparatus (approved), Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA016508
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane, endoplasmic reticulum & the Golgi apparatus.

Main location

Endoplasmic reticulum (approved), Golgi apparatus (approved), Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA016508	A-431	Endoplasmic reticulum
			Golgi apparatus
			Plasma membrane
	HPA016508	U-2 OS	Endoplasmic reticulum
			Golgi apparatus
			Plasma membrane
	HPA016508	U-251 MG	Endoplasmic reticulum
			Golgi apparatus
			Plasma membrane

GENE INFORMATION
Gene name	SLC39A14 (HGNC Symbol)
Synonyms	KIAA0062, NET34, ZIP14
Description	Solute carrier family 39 (zinc transporter), member 14 (HGNC Symbol)
Entrez gene summary	Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	22367249 - 22434129
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104635 (version 83.38)
Entrez gene	23516
UniProt	Q15043 (UniProt - Evidence at protein level)
neXtProt	NX_Q15043
Antibodypedia	SLC39A14 antibodies

PROTEIN BROWSER

SLC39A14-001	SLC39A14-002	SLC39A14-003	SLC39A14-004	SLC39A14-005	SLC39A14-006	SLC39A14-007	SLC39A14-008	SLC39A14-009	SLC39A14-010	SLC39A14-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC39A14-001 ENSP00000352779 ENST00000359741	Q15043 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006826 [iron ion transport] GO:0006829 [zinc II ion transport] GO:0006882 [cellular zinc ion homeostasis] GO:0015093 [ferrous iron transmembrane transporter activity] GO:0015684 [ferrous iron transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0030027 [lamellipodium] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:0071577 [zinc II ion transmembrane transport] GO:0071578 [zinc II ion transmembrane import] GO:1903874 [ferrous iron transmembrane transport] Show all	492 aa 54.1 kDa	Yes	6
SLC39A14-002 ENSP00000370635 ENST00000381237	Q15043 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006882 [cellular zinc ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0030027 [lamellipodium] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:0071577 [zinc II ion transmembrane transport] GO:0071578 [zinc II ion transmembrane import] Show all	492 aa 54.2 kDa	Yes	6
SLC39A14-003 ENSP00000240095 ENST00000240095	Q15043 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006882 [cellular zinc ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0030027 [lamellipodium] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:0071577 [zinc II ion transmembrane transport] GO:0071578 [zinc II ion transmembrane import] Show all	481 aa 52.8 kDa	Yes	5
SLC39A14-004 ENSP00000289952 ENST00000289952	Q15043 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005385 [zinc ion transmembrane transporter activity] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006882 [cellular zinc ion homeostasis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0030027 [lamellipodium] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:0071577 [zinc II ion transmembrane transport] GO:0071578 [zinc II ion transmembrane import] Show all	492 aa 54.2 kDa	Yes	6
SLC39A14-005 ENSP00000428789 ENST00000520644	E5RGA7 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 9.7 kDa	Yes	0
SLC39A14-006 ENSP00000430315 ENST00000524285	E5RFZ8 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 9.6 kDa	Yes	0
SLC39A14-007 ENSP00000428905 ENST00000520832	E5RFF5 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 5.8 kDa	Yes	0
SLC39A14-008 ENSP00000430629 ENST00000519960	E5RJ40 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13.3 kDa	Yes	0
SLC39A14-009 ENSP00000429328 ENST00000522881	E5RIP4 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 17 kDa	Yes	0
SLC39A14-010 ENSP00000430564 ENST00000517552	E5RJG5 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 13.8 kDa	Yes	0
SLC39A14-011 ENSP00000427981 ENST00000517370	E5RFT1 [Direct mapping] Zinc transporter ZIP14 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030001 [metal ion transport] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] Show all	202 aa 22.6 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.