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Few colorectal, breast, prostatic, skin, endometrial and stomach cancers showed weak to moderate cytoplasmic positivity. Other cancer tissues were negative.
GENE INFORMATION
Gene name
TNFRSF10A (HGNC Symbol)
Synonyms
Apo2, CD261, DR4, TRAILR-1
Description
Tumor necrosis factor receptor superfamily, member 10a (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]