Cell atlas - UBXN8 - The Human Protein Atlas

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UBXN8

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum
	Nucleoli

Human cell
	Endoplasmic Reticulum
	Nucleoli

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GENERAL INFORMATION
Gene name	UBXN8
Gene description	UBX domain protein 8
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the endoplasmic reticulum. In addition localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)
Additional location	In addition localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA077538
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the endoplasmic reticulum. In addition localized to the nucleoli.

Main location

Endoplasmic reticulum (supported)

Additional location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA077538	BJ	Endoplasmic reticulum
	HPA077538	U-2 OS	Nucleoli
	HPA077538	U-2 OS	Endoplasmic reticulum

GENE INFORMATION
Gene name	UBXN8 (HGNC Symbol)
Synonyms	D8S2298E, REP8, UBXD6
Description	UBX domain protein 8 (HGNC Symbol)
Entrez gene summary	p97 or VCP (valosin-containing protein) is a versatile ATPase complex, and many cofactors are required for the p97 functional diversity. This gene encodes one of the p97 cofactors. This cofactor is a transmembrane protein and localized in the endoplasmic reticulum (ER) membrane. It tethers p97 to the ER membrane via its UBX domain. The association of this cofactor with p97 facilitates efficient ER-associated degradation of misfolded proteins. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2013]
Chromosome	8
Cytoband	p12
Chromosome location (bp)	30732247 - 30767006
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104691 (version 83.38)
Entrez gene	7993
UniProt	O00124 (UniProt - Evidence at protein level)
neXtProt	NX_O00124
Antibodypedia	UBXN8 antibodies

PROTEIN BROWSER

UBXN8-002	UBXN8-003	UBXN8-004	UBXN8-008	UBXN8-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBXN8-002 ENSP00000479216 ENST00000265616	A0A087WV67 [Direct mapping] UBX domain-containing protein 8 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] Show all	270 aa 30.5 kDa	No	0
UBXN8-003 ENSP00000481635 ENST00000615729	O00124 [Direct mapping] UBX domain-containing protein 8 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0007338 [single fertilization] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] Show all	233 aa 26.5 kDa	Yes	0
UBXN8-004 ENSP00000478502 ENST00000341403	A0A087WUA4 [Direct mapping] UBX domain-containing protein 8 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	229 aa 25.7 kDa	No	0
UBXN8-008 ENSP00000477532 ENST00000620074	A0A087WT23 [Direct mapping] UBX domain-containing protein 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	310 aa 35.2 kDa	No	1
UBXN8-009 ENSP00000483433 ENST00000522968	A0A087X0J2 [Direct mapping] UBX domain-containing protein 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0003676 [nucleic acid binding] GO:0004523 [RNA-DNA hybrid ribonuclease activity] GO:0016021 [integral component of membrane] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	248 aa 27.6 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.