Expression of NEFM in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Neurofilament, medium polypeptide

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA022845	HPA023138	CAB010900	CAB012976

GENE INFORMATION
Gene name	NEFM (HGNC Symbol)
Synonyms	NEF3, NF-M, NFM
Description	Neurofilament, medium polypeptide (HGNC Symbol)
Entrez gene summary	Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Chromosome	8
Cytoband	p21.2
Chromosome location (bp)	24913012 - 24919098
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104722 (version 83.38)
Entrez gene	4741
UniProt	P07197 (UniProt - Evidence at protein level)
neXtProt	NX_P07197
Antibodypedia	NEFM antibodies

PROTEIN BROWSER

NEFM-001	NEFM-002	NEFM-003	NEFM-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NEFM-001 ENSP00000221166 ENST00000221166	P07197 [Direct mapping] Neurofilament medium polypeptide Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005882 [intermediate filament] GO:0005883 [neurofilament] GO:0008017 [microtubule binding] GO:0030424 [axon] GO:0033693 [neurofilament bundle assembly] GO:0097418 [neurofibrillary tangle] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	916 aa 102.5 kDa	No	0
NEFM-002 ENSP00000412295 ENST00000433454	P07197 [Direct mapping] Neurofilament medium polypeptide Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005882 [intermediate filament] GO:0005883 [neurofilament] GO:0008017 [microtubule binding] GO:0030424 [axon] GO:0033693 [neurofilament bundle assembly] GO:0097418 [neurofibrillary tangle] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	540 aa 59.5 kDa	No	0
NEFM-003 ENSP00000427872 ENST00000518131	E7EMV2 [Direct mapping] Neurofilament medium polypeptide Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] GO:0005883 [neurofilament] Show all	698 aa 78.9 kDa	No	0
NEFM-201 ENSP00000410137 ENST00000437366	E7ESP9 [Direct mapping] Neurofilament medium polypeptide Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005882 [intermediate filament] GO:0005883 [neurofilament] Show all	877 aa 98.4 kDa	No	0