Expression of BNIP3L in cancer - Summary

CANCER ATLAS

Gene description

BCL2/adenovirus E1B 19kDa interacting protein 3-like

Protein class

Cancer-related genes, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA015652	CAB025371

GENE INFORMATION
Gene name	BNIP3L (HGNC Symbol)
Synonyms	BNIP3a, Nix
Description	BCL2/adenovirus E1B 19kDa interacting protein 3-like (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
Chromosome	8
Cytoband	p21.2
Chromosome location (bp)	26382898 - 26505636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104765 (version 83.38)
Entrez gene	665
UniProt	O60238 (UniProt - Evidence at protein level)
neXtProt	NX_O60238
Antibodypedia	BNIP3L antibodies

PROTEIN BROWSER

BNIP3L-001	BNIP3L-002	BNIP3L-004	BNIP3L-006	BNIP3L-007	BNIP3L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BNIP3L-001 ENSP00000370003 ENST00000380629	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Q6IBV1 [Target identity:100%; Query identity:100%] BCL2/adenovirus E1B 19kDa interacting protein 3-like; BNIP3L protein; cDNA FLJ75547, highly similar to Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L), mRNA Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] GO:1903146 [regulation of mitophagy] GO:1903214 [regulation of protein targeting to mitochondrion] Show all	219 aa 23.9 kDa	No	1
BNIP3L-002 ENSP00000429698 ENST00000523515	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-004 ENSP00000429851 ENST00000518611	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-006 ENSP00000428597 ENST00000520409	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-007 ENSP00000429171 ENST00000523949	H0YBC7 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005740 [mitochondrial envelope] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	185 aa 20.1 kDa	No	1
BNIP3L-201 ENSP00000479522 ENST00000620910	A0A087WVL5 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005740 [mitochondrial envelope] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	229 aa 25.3 kDa	No	1