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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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KCNN4
  • TISSUE

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  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLASi

The cancer tissue page shows antibody staining in 20 different cancers. The assay and annotation is described here.

This page starts with information about the protein evidence and, when applicable, also protein class. Below the summary, a selection of four standard cancer tissue samples is displayed as representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional 5th image can be added as a complement.

For histological reference, visit the histological dictionary.

Gene description

Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4

Protein class

Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters, Voltage-gated ion channels

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARYi

The cancer tissue summary page shows antibody staining in 20 different cancers. The assay and annotation is described here.

For each cancer, the fraction of samples with antibody staining/protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The tooltip function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

At the bottom of the page, a summary of the overall protein expression pattern across the analyzed cancer tissues as well as information about literature conformity are presented.

HPA053841
HPA059622

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Few ases of cervical and urothelial showed moderate nuclear positivity. Remaining cancers were generally negative.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer cells were generally negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

KCNN4 (HGNC Symbol)

Synonyms

hIKCa1, hKCa4, hSK4, IK, KCa3.1

Description

Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

q13.31

Chromosome location (bp)

43766533 - 43781257

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000104783 (version 83.38)

Entrez gene

3783

UniProt

O15554 (UniProt - Evidence at protein level)

neXtProt

NX_O15554

Antibodypedia

KCNN4 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

KCNN4-001
KCNN4-010
KCNN4-013
KCNN4-201

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KCNN4-001
ENSP00000262888
ENST00000262888
O15554 [Direct mapping]
Intermediate conductance calcium-activated potassium channel protein 4
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Calcium-Activated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0005267 [potassium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0006816 [calcium ion transport]
GO:0006820 [anion transport]
GO:0006884 [cell volume homeostasis]
GO:0006952 [defense response]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0016286 [small conductance calcium-activated potassium channel activity]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019903 [protein phosphatase binding]
GO:0022894 [Intermediate conductance calcium-activated potassium channel activity]
GO:0030322 [stabilization of membrane potential]
GO:0043025 [neuronal cell body]
GO:0045121 [membrane raft]
GO:0045332 [phospholipid translocation]
GO:0046541 [saliva secretion]
GO:0050714 [positive regulation of protein secretion]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
Show all
427 aa
47.7 kDa
No 6
KCNN4-010
ENSP00000471900
ENST00000598836
M0R1J0 [Direct mapping]
Intermediate conductance calcium-activated potassium channel protein 4
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0022894 [Intermediate conductance calcium-activated potassium channel activity]
GO:0043025 [neuronal cell body]
GO:0071805 [potassium ion transmembrane transport]
Show all
165 aa
18.4 kDa
Yes 0
KCNN4-013
ENSP00000470339
ENST00000600909
M0QZ70 [Direct mapping]
Intermediate conductance calcium-activated potassium channel protein 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0022894 [Intermediate conductance calcium-activated potassium channel activity]
GO:0043025 [neuronal cell body]
GO:0071805 [potassium ion transmembrane transport]
Show all
59 aa
6.6 kDa
No 0
KCNN4-201
ENSP00000485014
ENST00000615047
D1MQ08 [Direct mapping]
Intermediate conductance calcium-activated potassium channel protein 4; Small conductance calcium activated potassium channel type 4 transcript variant 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0022894 [Intermediate conductance calcium-activated potassium channel activity]
GO:0043025 [neuronal cell body]
GO:0071805 [potassium ion transmembrane transport]
Show all
295 aa
33.4 kDa
No 3

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