Expression of KCNN4 in cancer - Summary

CANCER ATLAS

Gene description

Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4

Protein class

Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters, Voltage-gated ion channels

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA053841	HPA059622

GENE INFORMATION
Gene name	KCNN4 (HGNC Symbol)
Synonyms	hIKCa1, hKCa4, hSK4, IK, KCa3.1
Description	Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	43766533 - 43781257
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104783 (version 83.38)
Entrez gene	3783
UniProt	O15554 (UniProt - Evidence at protein level)
neXtProt	NX_O15554
Antibodypedia	KCNN4 antibodies

PROTEIN BROWSER

KCNN4-001	KCNN4-010	KCNN4-013	KCNN4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCNN4-001 ENSP00000262888 ENST00000262888	O15554 [Direct mapping] Intermediate conductance calcium-activated potassium channel protein 4 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Calcium-Activated Potassium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0002376 [immune system process] GO:0005267 [potassium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0006816 [calcium ion transport] GO:0006820 [anion transport] GO:0006884 [cell volume homeostasis] GO:0006952 [defense response] GO:0007268 [synaptic transmission] GO:0008076 [voltage-gated potassium channel complex] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0016286 [small conductance calcium-activated potassium channel activity] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0019903 [protein phosphatase binding] GO:0022894 [Intermediate conductance calcium-activated potassium channel activity] GO:0030322 [stabilization of membrane potential] GO:0043025 [neuronal cell body] GO:0045121 [membrane raft] GO:0045332 [phospholipid translocation] GO:0046541 [saliva secretion] GO:0050714 [positive regulation of protein secretion] GO:0050862 [positive regulation of T cell receptor signaling pathway] GO:0071435 [potassium ion export] GO:0071805 [potassium ion transmembrane transport] Show all	427 aa 47.7 kDa	No	6
KCNN4-010 ENSP00000471900 ENST00000598836	M0R1J0 [Direct mapping] Intermediate conductance calcium-activated potassium channel protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0022894 [Intermediate conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] Show all	165 aa 18.4 kDa	Yes	0
KCNN4-013 ENSP00000470339 ENST00000600909	M0QZ70 [Direct mapping] Intermediate conductance calcium-activated potassium channel protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0022894 [Intermediate conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] Show all	59 aa 6.6 kDa	No	0
KCNN4-201 ENSP00000485014 ENST00000615047	D1MQ08 [Direct mapping] Intermediate conductance calcium-activated potassium channel protein 4; Small conductance calcium activated potassium channel type 4 transcript variant 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0006813 [potassium ion transport] GO:0015269 [calcium-activated potassium channel activity] GO:0016021 [integral component of membrane] GO:0022894 [Intermediate conductance calcium-activated potassium channel activity] GO:0043025 [neuronal cell body] GO:0071805 [potassium ion transmembrane transport] Show all	295 aa 33.4 kDa	No	3