Cell atlas - NUCB1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NUCB1
Gene description	Nucleobindin 1
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus. In addition localized to the microtubules.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)
Additional location	In addition localized to the Microtubules (supported)
Mouse	Localized to the Golgi apparatus, Microtubules in mouse cells.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA008176
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus. In addition localized to the microtubules.

Main location

Golgi apparatus (supported)

Additional location

Microtubules (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA008176	SiHa	Golgi apparatus
HPA008176	SiHa	Microtubules
HPA008176	U-2 OS	Golgi apparatus
HPA008176	U-251 MG	Golgi apparatus

MOUSE CELLS

Main location

Golgi apparatus, Microtubules

Mouse gene

ENSMUSG00000030824 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA008176	NIH 3T3	Golgi apparatus
	HPA008176	NIH 3T3	Microtubules

GENE INFORMATION
Gene name	NUCB1 (HGNC Symbol)
Synonyms	Calnuc, NUC
Description	Nucleobindin 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48900050 - 48923372
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104805 (version 83.38)
Entrez gene	4924
UniProt	Q02818 (UniProt - Evidence at protein level)
neXtProt	NX_Q02818
Antibodypedia	NUCB1 antibodies

PROTEIN BROWSER

NUCB1-001	NUCB1-002	NUCB1-003	NUCB1-004	NUCB1-005	NUCB1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUCB1-001 ENSP00000385923 ENST00000405315	Q02818 [Direct mapping] Nucleobindin-1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001965 [G-protein alpha-subunit binding] GO:0003677 [DNA binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005769 [early endosome] GO:0005791 [rough endoplasmic reticulum] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0005798 [Golgi-associated vesicle] GO:0005801 [cis-Golgi network] GO:0005802 [trans-Golgi network] GO:0015630 [microtubule cytoskeleton] GO:0016020 [membrane] GO:0032580 [Golgi cisterna membrane] GO:0070062 [extracellular exosome] GO:0072718 [response to cisplatin] GO:0090498 [extrinsic component of Golgi membrane] GO:0098547 [lumenal side of Golgi membrane] GO:1903533 [regulation of protein targeting] Show all	461 aa 53.9 kDa	Yes	0
NUCB1-002 ENSP00000385211 ENST00000407032	Q02818 [Direct mapping] Nucleobindin-1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment] GO:0005794 [Golgi apparatus] GO:0015630 [microtubule cytoskeleton] GO:0016020 [membrane] GO:0070062 [extracellular exosome] Show all	461 aa 53.9 kDa	Yes	0
NUCB1-003 ENSP00000410519 ENST00000411700	C9J3C1 [Direct mapping] Nucleobindin-1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 14.1 kDa	Yes	0
NUCB1-004 ENSP00000397201 ENST00000451312	C9JBD3 [Direct mapping] Nucleobindin-1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		111 aa 12.5 kDa	Yes	0
NUCB1-005 ENSP00000389007 ENST00000452087	C9JKZ2 [Direct mapping] Nucleobindin-1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		268 aa 31.2 kDa	Yes	0
NUCB1-006 ENSP00000389734 ENST00000424608	H7BZI1 [Direct mapping] Nucleobindin-1 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] Show all	295 aa 34.8 kDa	Yes	0