Expression of GYS1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Glycogen synthase 1 (muscle)

Protein class

Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041598	CAB007793

GENE INFORMATION
Gene name	GYS1 (HGNC Symbol)
Synonyms	GSY, GYS
Description	Glycogen synthase 1 (muscle) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48968125 - 48993310
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104812 (version 83.38)
Entrez gene	2997
UniProt	P13807 (UniProt - Evidence at protein level)
neXtProt	NX_P13807
Antibodypedia	GYS1 antibodies

PROTEIN BROWSER

GYS1-001	GYS1-006	GYS1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GYS1-001 ENSP00000317904 ENST00000323798	P13807 [Direct mapping] Glycogen [starch] synthase, muscle Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004373 [glycogen (starch) synthase activity] GO:0005515 [protein binding] GO:0005536 [glucose binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005977 [glycogen metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0007507 [heart development] GO:0016020 [membrane] GO:0016234 [inclusion body] GO:0019901 [protein kinase binding] GO:0044281 [small molecule metabolic process] GO:0061547 [glycogen synthase activity, transferring glucose-1-phosphate] Show all	737 aa 83.8 kDa	No	0
GYS1-006 ENSP00000263276 ENST00000263276	P13807 [Direct mapping] Glycogen [starch] synthase, muscle Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004373 [glycogen (starch) synthase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005975 [carbohydrate metabolic process] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0044281 [small molecule metabolic process] GO:0061547 [glycogen synthase activity, transferring glucose-1-phosphate] Show all	673 aa 76.5 kDa	No	0
GYS1-007 ENSP00000470072 ENST00000594220	M0QYU1 [Direct mapping] Glycogen [starch] synthase, muscle Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004373 [glycogen (starch) synthase activity] GO:0005737 [cytoplasm] GO:0005978 [glycogen biosynthetic process] Show all	113 aa 13.2 kDa	No	0