Fields »
ABOUT
HELP
BLOG
TUBB4A

GENERAL INFORMATION

Gene name

 TUBB4A

Gene description

 Tubulin, beta 4A class IVa

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, adrenal gland)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Group enriched (cerebellum, brain, caudate, hippocampus, testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in CNS and testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Reliability score

 Approved based on 3 antibodies.
HPA043640 , HPA046280 , CAB010768
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, adrenal gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, brain, caudate, hippocampus, testis)

GENE INFORMATION

Gene name

 TUBB4A (HGNC Symbol)

Synonyms

 beta-5, DYT4, TUBB4

Description

 Tubulin, beta 4A class IVa (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 6494319 - 6502848

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104833 (version 83.38)

Entrez gene

 10382

UniProt

 P04350 (UniProt - Evidence at protein level)

neXtProt

 NX_P04350

Antibodypedia

 TUBB4A antibodies

PROTEIN BROWSER
«
TUBB4A-001
TUBB4A-004
TUBB4A-005
TUBB4A-006
TUBB4A-007
TUBB4A-008
TUBB4A-009
TUBB4A-010
TUBB4A-013
TUBB4A-014
TUBB4A-015
TUBB4A-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TUBB4A-001
ENSP00000264071
ENST00000264071
P04350 [Direct mapping]
Tubulin beta-4A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005929 [cilium]
GO:0006457 [protein folding]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0033269 [internode region of axon]
GO:0042995 [cell projection]
GO:0043025 [neuronal cell body]
GO:0043209 [myelin sheath]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
Show all
 444 aa
49.6 kDa 		No 0
TUBB4A-004
ENSP00000469660
ENST00000601640
M0QY85 [Direct mapping]
Tubulin beta-4A chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 107 aa
11.8 kDa 		No 0
TUBB4A-005
ENSP00000472375
ENST00000597686
M0R278 [Direct mapping]
Tubulin beta-4A chain
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 167 aa
17.6 kDa 		No 0
TUBB4A-006
ENSP00000470627
ENST00000598635
M0QZL7 [Direct mapping]
Tubulin beta-4A chain
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 158 aa
16.7 kDa 		No 0
TUBB4A-007
ENSP00000471320
ENST00000601152
M0R0M1 [Direct mapping]
Tubulin beta-4A chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 93 aa
10.6 kDa 		No 0
TUBB4A-008
ENSP00000472795
ENST00000598006
M0R2T4 [Direct mapping]
Tubulin beta-4A chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0008152 [metabolic process]
Show all
 104 aa
11.7 kDa 		No 0
TUBB4A-009
ENSP00000469936
ENST00000594075
M0QYM7 [Direct mapping]
Tubulin beta-4A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 161 aa
17.8 kDa 		No 0
TUBB4A-010
ENSP00000472481
ENST00000594276
M0R2D3 [Direct mapping]
Tubulin beta-4A chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 155 aa
17.4 kDa 		No 0
TUBB4A-013
ENSP00000468843
ENST00000596926
M0QX14 [Direct mapping]
Tubulin beta-4A chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 110 aa
12.2 kDa 		No 0
TUBB4A-014
ENSP00000471880
ENST00000596291
M0R1I1 [Direct mapping]
Tubulin beta-4A chain
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 74 aa
7.8 kDa 		No 0
TUBB4A-015
ENSP00000470983
ENST00000600216
M0R042 [Direct mapping]
Tubulin beta-4A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005525 [GTP binding]
GO:0005874 [microtubule]
GO:0007017 [microtubule-based process]
GO:0008152 [metabolic process]
Show all
 144 aa
15.8 kDa 		No 0
TUBB4A-201
ENSP00000443590
ENST00000540257
P04350 [Direct mapping]
Tubulin beta-4A chain
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0003924 [GTPase activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0006457 [protein folding]
GO:0006996 [organelle organization]
GO:0007017 [microtubule-based process]
GO:0043234 [protein complex]
GO:0044267 [cellular protein metabolic process]
GO:0051084 ['de novo' posttranslational protein folding]
GO:0051258 [protein polymerization]
GO:0070062 [extracellular exosome]
Show all
 444 aa
49.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.