Fields »
ABOUT
HELP
BLOG
SARS2

GENERAL INFORMATION

Gene name

 SARS2

Gene description

 Seryl-tRNA synthetase 2, mitochondrial

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Not detected
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General granular cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 2 antibodies.
HPA052730 , HPA056957
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SARS2 (HGNC Symbol)

Synonyms

 FLJ20450, mtSerRS, SARS, SARSM, SerRSmt, SERS, SYS

Description

 Seryl-tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 38915266 - 38930896

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104835 (version 83.38)

Entrez gene

 54938

UniProt

 Q9NP81 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NP81

Antibodypedia

 SARS2 antibodies

PROTEIN BROWSER
SARS2-001
SARS2-003
SARS2-005
SARS2-006
SARS2-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SARS2-001
ENSP00000221431
ENST00000221431
Q9NP81 [Direct mapping]
Serine--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004828 [serine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006434 [seryl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0044822 [poly(A) RNA binding]
GO:0097056 [selenocysteinyl-tRNA(Sec) biosynthetic process]
Show all
 518 aa
58.3 kDa 		No 0
SARS2-003
ENSP00000472847
ENST00000600042
Q9NP81 [Direct mapping]
Serine--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004828 [serine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006434 [seryl-tRNA aminoacylation]
GO:0010467 [gene expression]
GO:0044822 [poly(A) RNA binding]
GO:0097056 [selenocysteinyl-tRNA(Sec) biosynthetic process]
Show all
 520 aa
58 kDa 		No 0
SARS2-005
ENSP00000406754
ENST00000430193
M0QWZ7 [Direct mapping]
Serine--tRNA ligase, mitochondrial; Seryl-tRNA synthetase 2, isoform CRA_d
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004828 [serine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006434 [seryl-tRNA aminoacylation]
Show all
 518 aa
58.2 kDa 		No 0
SARS2-006
ENSP00000472339
ENST00000594171
M0R259 [Direct mapping]
Serine--tRNA ligase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004828 [serine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006434 [seryl-tRNA aminoacylation]
Show all
 328 aa
36.4 kDa 		No 0
SARS2-014
ENSP00000468865
ENST00000598831
M0QX29 [Direct mapping]
Serine--tRNA ligase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004828 [serine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006434 [seryl-tRNA aminoacylation]
Show all
 187 aa
20.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.