Expression of FCGRT in cancer - Summary

CANCER ATLAS

Gene description

Fc fragment of IgG, receptor, transporter, alpha

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA012122	HPA015130

GENE INFORMATION
Gene name	FCGRT (HGNC Symbol)
Synonyms	alpha-chain, FCRN
Description	Fc fragment of IgG, receptor, transporter, alpha (HGNC Symbol)
Entrez gene summary	This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49506816 - 49526333
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104870 (version 83.38)
Entrez gene	2217
UniProt	P55899 (UniProt - Evidence at protein level)
neXtProt	NX_P55899
Antibodypedia	FCGRT antibodies

PROTEIN BROWSER

FCGRT-001	FCGRT-004	FCGRT-009	FCGRT-010	FCGRT-012	FCGRT-013	FCGRT-014	FCGRT-016	FCGRT-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FCGRT-001 ENSP00000221466 ENST00000221466	P55899 [Direct mapping] IgG receptor FcRn large subunit p51 A0A024QZI2 [Target identity:100%; Query identity:100%] HCG1998059, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002416 [IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0019770 [IgG receptor activity] GO:0019864 [IgG binding] GO:0030881 [beta-2-microglobulin binding] GO:0038094 [Fc-gamma receptor signaling pathway] Show all	365 aa 39.7 kDa	Yes	1
FCGRT-004 ENSP00000410798 ENST00000426395	P55899 [Direct mapping] IgG receptor FcRn large subunit p51 A0A024QZI2 [Target identity:100%; Query identity:100%] HCG1998059, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002416 [IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006955 [immune response] GO:0016021 [integral component of membrane] GO:0019770 [IgG receptor activity] GO:0019864 [IgG binding] GO:0030881 [beta-2-microglobulin binding] GO:0038094 [Fc-gamma receptor signaling pathway] Show all	365 aa 39.7 kDa	Yes	1
FCGRT-009 ENSP00000472350 ENST00000598491	M0R266 [Direct mapping] IgG receptor FcRn large subunit p51 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006955 [immune response] Show all	141 aa 15.5 kDa	Yes	0
FCGRT-010 ENSP00000469933 ENST00000600273	M0QYM4 [Direct mapping] IgG receptor FcRn large subunit p51 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006955 [immune response] Show all	167 aa 18.5 kDa	Yes	0
FCGRT-012 ENSP00000472794 ENST00000599701	M0R2T3 [Direct mapping] IgG receptor FcRn large subunit p51 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		39 aa 4.5 kDa	No	0
FCGRT-013 ENSP00000471118 ENST00000596975	M0R0A9 [Direct mapping] IgG receptor FcRn large subunit p51 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0006955 [immune response] GO:0016021 [integral component of membrane] Show all	273 aa 29.3 kDa	Yes	1
FCGRT-014 ENSP00000472256 ENST00000593381	M0R220 [Direct mapping] IgG receptor FcRn large subunit p51 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006955 [immune response] Show all	189 aa 21.1 kDa	No	0
FCGRT-016 ENSP00000471232 ENST00000598076	M0R0H0 [Direct mapping] IgG receptor FcRn large subunit p51 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006955 [immune response] Show all	153 aa 17.1 kDa	No	0
FCGRT-020 ENSP00000471300 ENST00000599988	M0R0K7 [Direct mapping] IgG receptor FcRn large subunit p51 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	99 aa 10.1 kDa	Yes	1