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ARHGEF18

GENERAL INFORMATION

Gene name

 ARHGEF18

Gene description

 Rho/Rac guanine nucleotide exchange factor (GEF) 18

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression in several tissues, including lymphoid tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA042689
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARHGEF18 (HGNC Symbol)

Synonyms

 KIAA0521, MGC15913, P114-RhoGEF

Description

 Rho/Rac guanine nucleotide exchange factor (GEF) 18 (HGNC Symbol)

Entrez gene summary

 Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 7395113 - 7472477

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104880 (version 83.38)

Entrez gene

 23370

UniProt

 Q6ZSZ5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6ZSZ5

Antibodypedia

 ARHGEF18 antibodies

PROTEIN BROWSER
ARHGEF18-001
ARHGEF18-002
ARHGEF18-003
ARHGEF18-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF18-001
ENSP00000352995
ENST00000359920
Q6ZSZ5 [Direct mapping]
Rho guanine nucleotide exchange factor 18
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0016324 [apical plasma membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045177 [apical part of cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
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 1173 aa
130.8 kDa 		No 0
ARHGEF18-002
ENSP00000319200
ENST00000319670
Q6ZSZ5 [Direct mapping]
Rho guanine nucleotide exchange factor 18
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0016324 [apical plasma membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045177 [apical part of cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
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 1015 aa
114.1 kDa 		No 0
ARHGEF18-003
ENSP00000470729
ENST00000594665
M0QZS0 [Direct mapping]
Rho guanine nucleotide exchange factor 18
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 812 aa
91.3 kDa 		No 0
ARHGEF18-006
ENSP00000471597
ENST00000599752
M0R125 [Direct mapping]
Rho guanine nucleotide exchange factor 18
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 87 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.