Expression of SF3A2 in cancer - Summary

CANCER ATLAS

Gene description

Splicing factor 3a, subunit 2, 66kDa

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042843	HPA049439

GENE INFORMATION
Gene name	SF3A2 (HGNC Symbol)
Synonyms	Prp11, PRPF11, SAP62, SF3a66
Description	Splicing factor 3a, subunit 2, 66kDa (HGNC Symbol)
Entrez gene summary	This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	2236504 - 2248679
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104897 (version 83.38)
Entrez gene	8175
UniProt	Q15428 (UniProt - Evidence at protein level)
neXtProt	NX_Q15428
Antibodypedia	SF3A2 antibodies

PROTEIN BROWSER

SF3A2-001	SF3A2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SF3A2-001 ENSP00000221494 ENST00000221494	Q15428 [Direct mapping] Splicing factor 3A subunit 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000389 [mRNA 3'-splice site recognition] GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005681 [spliceosomal complex] GO:0005686 [U2 snRNP] GO:0006397 [mRNA processing] GO:0008270 [zinc ion binding] GO:0008380 [RNA splicing] GO:0010467 [gene expression] GO:0010976 [positive regulation of neuron projection development] GO:0016607 [nuclear speck] GO:0030532 [small nuclear ribonucleoprotein complex] GO:0044822 [poly(A) RNA binding] GO:0071004 [U2-type prespliceosome] GO:0071013 [catalytic step 2 spliceosome] Show all	464 aa 49.3 kDa	No	0
SF3A2-002 ENSP00000466634 ENST00000586396	K7EMT0 [Direct mapping] Splicing factor 3A subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] Show all	135 aa 15.2 kDa	No	0