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Most malignant cells displayed weak to moderate cytoplasmic immunoreactivity. Luminal membranous staining was observed in several malignancies, including pancreatic and colorectal cancers. Several pancreatic cancers along with a few gastric and liver cancers were strongly stained.
GENE INFORMATION
Gene name
OAZ1 (HGNC Symbol)
Synonyms
AZI, MGC138338, OAZ
Description
Ornithine decarboxylase antizyme 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
