Expression of OAZ1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Ornithine decarboxylase antizyme 1

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA009291

GENE INFORMATION
Gene name	OAZ1 (HGNC Symbol)
Synonyms	AZI, MGC138338, OAZ
Description	Ornithine decarboxylase antizyme 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	2269509 - 2273490
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104904 (version 83.38)
Entrez gene	4946
UniProt	P54368 (UniProt - Evidence at protein level)
neXtProt	NX_P54368
Antibodypedia	OAZ1 antibodies

PROTEIN BROWSER

OAZ1-001	OAZ1-002	OAZ1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OAZ1-001 ENSP00000468437 ENST00000588673	K7ERW1 [Direct mapping] Ornithine decarboxylase antizyme 1 Show all	Predicted intracellular proteins Show all	GO:0004857 [enzyme inhibitor activity] GO:0005829 [cytosol] GO:0006595 [polyamine metabolic process] GO:0008073 [ornithine decarboxylase inhibitor activity] GO:0043086 [negative regulation of catalytic activity] Show all	209 aa 22.2 kDa	No	0
OAZ1-002 ENSP00000473381 ENST00000602676	P54368 [Direct mapping] Ornithine decarboxylase antizyme 1 Show all	Predicted intracellular proteins Plasma proteins Show all	GO:0004857 [enzyme inhibitor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006521 [regulation of cellular amino acid metabolic process] GO:0006595 [polyamine metabolic process] GO:0006596 [polyamine biosynthetic process] GO:0006810 [transport] GO:0008073 [ornithine decarboxylase inhibitor activity] GO:0034641 [cellular nitrogen compound metabolic process] GO:0043086 [negative regulation of catalytic activity] GO:0044281 [small molecule metabolic process] GO:0045732 [positive regulation of protein catabolic process] GO:0090316 [positive regulation of intracellular protein transport] GO:1902268 [negative regulation of polyamine transmembrane transport] Show all	228 aa 25.4 kDa	No	0
OAZ1-004 ENSP00000463955 ENST00000582888	J3QQY4 [Direct mapping] Ornithine decarboxylase antizyme 1 Show all	Predicted intracellular proteins Show all	GO:0004857 [enzyme inhibitor activity] GO:0005829 [cytosol] GO:0006595 [polyamine metabolic process] GO:0008073 [ornithine decarboxylase inhibitor activity] GO:0043086 [negative regulation of catalytic activity] Show all	226 aa 25.2 kDa	No	0