Tissue expression of RETN - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RETN
Gene description	Resistin
Protein class	Candidate cardiovascular disease genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (bone marrow)
GTEx:	Group enriched (spleen, lung)
FANTOM5:	Tissue enhanced (heart muscle, spleen, lung)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (spleen, lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (heart muscle, spleen, lung)

GENE INFORMATION
Gene name	RETN (HGNC Symbol)
Synonyms	ADSF, FIZZ3, RETN1
Description	Resistin (HGNC Symbol)
Entrez gene summary	This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	7669044 - 7670454
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104918 (version 83.38)
Entrez gene	56729
UniProt	Q9HD89 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HD89
Antibodypedia	RETN antibodies

PROTEIN BROWSER

RETN-001	RETN-002	RETN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RETN-001 ENSP00000221515 ENST00000221515	Q9HD89 [Direct mapping] Resistin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0007568 [aging] GO:0008150 [biological_process] GO:0009612 [response to mechanical stimulus] GO:0010714 [positive regulation of collagen metabolic process] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0032868 [response to insulin] GO:0045444 [fat cell differentiation] GO:0048661 [positive regulation of smooth muscle cell proliferation] GO:0050806 [positive regulation of synaptic transmission] GO:0070062 [extracellular exosome] GO:2000252 [negative regulation of feeding behavior] GO:2000872 [positive regulation of progesterone secretion] Show all	108 aa 11.4 kDa	Yes	0
RETN-002 ENSP00000370725 ENST00000381324	Q9HD89 [Direct mapping] Resistin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0008150 [biological_process] GO:0070062 [extracellular exosome] Show all	82 aa 8.7 kDa	Yes	0
RETN-201 ENSP00000485998 ENST00000629642	Q9HD89 [Direct mapping] Resistin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0008150 [biological_process] GO:0070062 [extracellular exosome] Show all	82 aa 8.7 kDa	Yes	0