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Malignant cells were mainly negative. Strong cytoplasmic and membranous staining was found in a few cases of malignant lymphomas whereas a few cases of malignant gliomas displayed strong nuclear positivity.
Strong cytoplasmic and membranous positivity was observed in some malignant lymphomas. Remaining malignant cells were in general negative.
GENE INFORMATION
Gene name
FCER2 (HGNC Symbol)
Synonyms
CD23, CD23A, CLEC4J, FCE2
Description
Fc fragment of IgE, low affinity II, receptor for (CD23) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
P06734 [Direct mapping] Low affinity immunoglobulin epsilon Fc receptor Low affinity immunoglobulin epsilon Fc receptor membrane-bound form Low affinity immunoglobulin epsilon Fc receptor soluble form
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CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002925 [positive regulation of humoral immune response mediated by circulating immunoglobulin] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007219 [Notch signaling pathway] GO:0009897 [external side of plasma membrane] GO:0019863 [IgE binding] GO:0030246 [carbohydrate binding] GO:0046872 [metal ion binding] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051712 [positive regulation of killing of cells of other organism] GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process] GO:0070062 [extracellular exosome]
P06734 [Direct mapping] Low affinity immunoglobulin epsilon Fc receptor Low affinity immunoglobulin epsilon Fc receptor membrane-bound form Low affinity immunoglobulin epsilon Fc receptor soluble form
Show all
CD markers MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007219 [Notch signaling pathway] GO:0019863 [IgE binding] GO:0030246 [carbohydrate binding] GO:0046872 [metal ion binding] GO:0051000 [positive regulation of nitric-oxide synthase activity] GO:0051712 [positive regulation of killing of cells of other organism] GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process] GO:0070062 [extracellular exosome]
