Cell atlas - AES - The Human Protein Atlas

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AES

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	AES
Gene description	Amino-terminal enhancer of split
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA049499
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA049499	A549	Nucleoplasm
	HPA049499	U-2 OS	Nucleoplasm
	HPA049499	U-251 MG	Nucleoplasm

GENE INFORMATION
Gene name	AES (HGNC Symbol)
Synonyms	GRG5, TLE5
Description	Amino-terminal enhancer of split (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	3052910 - 3063107
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104964 (version 83.38)
Entrez gene	166
UniProt	Q08117 (UniProt - Evidence at protein level)
neXtProt	NX_Q08117
Antibodypedia	AES antibodies

PROTEIN BROWSER

AES-001	AES-003	AES-004	AES-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AES-001 ENSP00000221561 ENST00000221561	Q08117 [Direct mapping] Amino-terminal enhancer of split Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001501 [skeletal system development] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007275 [multicellular organismal development] GO:0009887 [organ morphogenesis] GO:0010629 [negative regulation of gene expression] GO:0016055 [Wnt signaling pathway] GO:0031668 [cellular response to extracellular stimulus] GO:0032091 [negative regulation of protein binding] GO:0040008 [regulation of growth] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0060761 [negative regulation of response to cytokine stimulus] GO:0070555 [response to interleukin-1] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000210 [positive regulation of anoikis] Show all	264 aa 29.1 kDa	No	0
AES-003 ENSP00000317537 ENST00000327141	Q08117 [Direct mapping] Amino-terminal enhancer of split Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0009887 [organ morphogenesis] GO:0010629 [negative regulation of gene expression] GO:0016055 [Wnt signaling pathway] GO:0032091 [negative regulation of protein binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0060761 [negative regulation of response to cytokine stimulus] GO:0070555 [response to interleukin-1] GO:0090090 [negative regulation of canonical Wnt signaling pathway] GO:2000210 [positive regulation of anoikis] Show all	197 aa 22 kDa	No	0
AES-004 ENSP00000466038 ENST00000586742	K7ELE3 [Direct mapping] Amino-terminal enhancer of split Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	264 aa 28.6 kDa	No	0
AES-009 ENSP00000467831 ENST00000586839	K7EQH5 [Direct mapping] Amino-terminal enhancer of split; Amino-terminal enhancer of split, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	141 aa 15.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.