Cell atlas - ASF1B - The Human Protein Atlas

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ASF1B

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	ASF1B
Gene description	Anti-silencing function 1B histone chaperone
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA054036
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054036	A-431	Nucleoplasm
	HPA054036	HeLa	Nucleoplasm
	HPA054036	U-2 OS	Nucleoplasm

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000005470 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA054036	NIH 3T3	No staining

GENE INFORMATION
Gene name	ASF1B (HGNC Symbol)
Synonyms	FLJ10604
Description	Anti-silencing function 1B histone chaperone (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell cycle-regulated kinases, and may play a key role in modulating the nucleosome structure of chromatin by ensuring a constant supply of histones at sites of nucleosome assembly. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.12
Chromosome location (bp)	14119509 - 14136956
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105011 (version 83.38)
Entrez gene	55723
UniProt	Q9NVP2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVP2
Antibodypedia	ASF1B antibodies

PROTEIN BROWSER

ASF1B-001	ASF1B-002	ASF1B-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ASF1B-001 ENSP00000263382 ENST00000263382	Q9NVP2 [Direct mapping] Histone chaperone ASF1B A0A024R7G4 [Target identity:100%; Query identity:100%] ASF1 anti-silencing function 1 homolog B (S. cerevisiae), isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000785 [chromatin] GO:0000790 [nuclear chromatin] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006333 [chromatin assembly or disassembly] GO:0006334 [nucleosome assembly] GO:0006335 [DNA replication-dependent nucleosome assembly] GO:0006336 [DNA replication-independent nucleosome assembly] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0016568 [chromatin modification] GO:0030154 [cell differentiation] GO:0042393 [histone binding] GO:0043234 [protein complex] Show all	202 aa 22.4 kDa	No	0
ASF1B-002 ENSP00000466257 ENST00000474890	K7ELW9 [Direct mapping] Histone chaperone ASF1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0006333 [chromatin assembly or disassembly] Show all	165 aa 18.3 kDa	No	0
ASF1B-005 ENSP00000468513 ENST00000592798	K7ES22 [Direct mapping] Histone chaperone ASF1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006333 [chromatin assembly or disassembly] Show all	143 aa 15.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.