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VRK3

CANCER ATLAS

Gene description

 Vaccinia related kinase 3

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA056489

GENE INFORMATION

Gene name

 VRK3

Synonyms

Description

 Vaccinia related kinase 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 49976467 - 50025946

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105053 (version 83.38)

Entrez gene

 51231

UniProt

 Q8IV63 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IV63

Antibodypedia

 VRK3 antibodies

PROTEIN BROWSER
«
VRK3-001
VRK3-002
VRK3-004
VRK3-005
VRK3-006
VRK3-007
VRK3-008
VRK3-009
VRK3-014
VRK3-016
VRK3-017
VRK3-019
VRK3-021
VRK3-022
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VRK3-001
ENSP00000324636
ENST00000316763
Q8IV63 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
A0A024QZI4 [Target identity:100%; Query identity:100%]
Vaccinia related kinase 3, isoform CRA_a
Show all
Enzymes
   Kinases
   CK1 Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019903 [protein phosphatase binding]
Show all
 474 aa
52.9 kDa 		No 0
VRK3-002
ENSP00000366210
ENST00000377011
Q8IV63 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Enzymes
   Kinases
   CK1 Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019903 [protein phosphatase binding]
Show all
 424 aa
47.5 kDa 		No 0
VRK3-004
ENSP00000472541
ENST00000594092
Q8IV63 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Enzymes
   Kinases
   CK1 Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019903 [protein phosphatase binding]
Show all
 412 aa
45.9 kDa 		No 0
VRK3-005
ENSP00000471061
ENST00000601912
M0R073 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 362 aa
40.5 kDa 		No 0
VRK3-006
ENSP00000470156
ENST00000601341
Q8IV63 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Enzymes
   Kinases
   CK1 Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019903 [protein phosphatase binding]
Show all
 424 aa
47.5 kDa 		No 0
VRK3-007
ENSP00000473171
ENST00000594948
Q8IV63 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
A0A024QZI4 [Target identity:100%; Query identity:100%]
Vaccinia related kinase 3, isoform CRA_a
Show all
Enzymes
   Kinases
   CK1 Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019903 [protein phosphatase binding]
Show all
 474 aa
52.9 kDa 		No 0
VRK3-008
ENSP00000469710
ENST00000593919
M0QYA8 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 406 aa
45.2 kDa 		No 0
VRK3-009
ENSP00000469880
ENST00000599538
Q8IV63 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
A0A024QZI4 [Target identity:100%; Query identity:100%]
Vaccinia related kinase 3, isoform CRA_a
Show all
Enzymes
   Kinases
   CK1 Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019903 [protein phosphatase binding]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
Show all
 474 aa
52.9 kDa 		No 0
VRK3-014
ENSP00000470359
ENST00000601324
M0QZ79 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 112 aa
12 kDa 		No 0
VRK3-016
ENSP00000468979
ENST00000600137
M0QX88 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 178 aa
19.5 kDa 		No 0
VRK3-017
ENSP00000470940
ENST00000597215
M0R025 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 182 aa
19.9 kDa 		No 0
VRK3-019
ENSP00000469400
ENST00000600259
M0QXV1 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 150 aa
16.4 kDa 		No 0
VRK3-021
ENSP00000473222
ENST00000593912
M0R3H2 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 117 aa
13.2 kDa 		No 0
VRK3-022
ENSP00000469092
ENST00000596445
M0QXD7 [Direct mapping]
Inactive serine/threonine-protein kinase VRK3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004674 [protein serine/threonine kinase activity]
GO:0005737 [cytoplasm]
GO:0006897 [endocytosis]
GO:0008360 [regulation of cell shape]
GO:0016055 [Wnt signaling pathway]
GO:0018105 [peptidyl-serine phosphorylation]
Show all
 169 aa
18.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.