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This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]
P31944 [Direct mapping] Caspase-14 Caspase-14 subunit p17, mature form Caspase-14 subunit p10, mature form Caspase-14 subunit p20, intermediate form Caspase-14 subunit p8, intermediate form B2CIS9 [Target identity:100%; Query identity:100%] Caspase 14, apoptosis-related cysteine peptidase; Caspase-14; cDNA, FLJ94644, Homo sapiens caspase 14, apoptosis-related cysteine protease(CASP14), mRNA
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Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004197 [cysteine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0008234 [cysteine-type peptidase activity] GO:0008544 [epidermis development] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0031424 [keratinization] GO:0045095 [keratin filament] GO:0070062 [extracellular exosome] GO:0070268 [cornification] GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand] GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
