Cell atlas - DYRK1B - The Human Protein Atlas

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DYRK1B

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleus

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DYRK1B
Gene description	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleus.
RNA cell category	Cell line enhanced (SH-SY5Y, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA028522
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SH-SY5Y, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleus.

Main location

Nucleus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA028522	SH-SY5Y	Nucleus	Intensity
	HPA028522	U-2 OS	No staining

GENE INFORMATION
Gene name	DYRK1B (HGNC Symbol)
Synonyms	MIRK
Description	Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	39825350 - 39834201
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105204 (version 83.38)
Entrez gene	9149
UniProt	Q9Y463 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y463
Antibodypedia	DYRK1B antibodies

PROTEIN BROWSER

DYRK1B-001	DYRK1B-003	DYRK1B-005	DYRK1B-006	DYRK1B-007	DYRK1B-008	DYRK1B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DYRK1B-001 ENSP00000312789 ENST00000323039	Q9Y463 [Direct mapping] Dual specificity tyrosine-phosphorylation-regulated kinase 1B A0A024R0I0 [Target identity:100%; Query identity:100%] Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060612 [adipose tissue development] Show all	629 aa 69.2 kDa	No	0
DYRK1B-003 ENSP00000472861 ENST00000601972	M0R2X3 [Direct mapping] Dual-specificity tyrosine-phosphorylation-regulated kinase 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 15.8 kDa	No	0
DYRK1B-005 ENSP00000471609 ENST00000600611	M0R131 [Direct mapping] Dual-specificity tyrosine-phosphorylation-regulated kinase 1B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	172 aa 19.9 kDa	No	0
DYRK1B-006 ENSP00000469863 ENST00000593685	Q9Y463 [Direct mapping] Dual specificity tyrosine-phosphorylation-regulated kinase 1B A0A024R0I0 [Target identity:100%; Query identity:100%] Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0007520 [myoblast fusion] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060612 [adipose tissue development] Show all	629 aa 69.2 kDa	No	0
DYRK1B-007 ENSP00000403182 ENST00000430012	Q9Y463 [Direct mapping] Dual specificity tyrosine-phosphorylation-regulated kinase 1B A0A024R0J6 [Target identity:100%; Query identity:100%] Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, isoform CRA_c Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060612 [adipose tissue development] Show all	589 aa 64.9 kDa	No	0
DYRK1B-008 ENSP00000472941 ENST00000597639	Q9Y463 [Direct mapping] Dual specificity tyrosine-phosphorylation-regulated kinase 1B A0A024R0M8 [Target identity:100%; Query identity:100%] Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, isoform CRA_e Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060612 [adipose tissue development] Show all	601 aa 66.3 kDa	No	0
DYRK1B-201 ENSP00000221803 ENST00000348817	Q9Y463 [Direct mapping] Dual specificity tyrosine-phosphorylation-regulated kinase 1B A0A024R0M8 [Target identity:100%; Query identity:100%] Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B, isoform CRA_e Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004712 [protein serine/threonine/tyrosine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0060612 [adipose tissue development] Show all	601 aa 66.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.