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A majority of malignant cells showed moderate to strong cytoplasmic immunoreactivity with a granular pattern. Most cases of squamous cell carcinomas, liver, pancreatic, gastric and endomatrial cancers were weakly stained or negative.
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0006970 [response to osmotic stress] GO:0007165 [signal transduction] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0009967 [positive regulation of signal transduction] GO:0010628 [positive regulation of gene expression] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0014850 [response to muscle activity] GO:0030334 [regulation of cell migration] GO:0030335 [positive regulation of cell migration] GO:0031340 [positive regulation of vesicle fusion] GO:0031667 [response to nutrient levels] GO:0031982 [vesicle] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032287 [peripheral nervous system myelin maintenance] GO:0032587 [ruffle membrane] GO:0032593 [insulin-responsive compartment] GO:0032868 [response to insulin] GO:0032869 [cellular response to insulin stimulus] GO:0032870 [cellular response to hormone stimulus] GO:0033119 [negative regulation of RNA splicing] GO:0033138 [positive regulation of peptidyl-serine phosphorylation] GO:0043066 [negative regulation of apoptotic process] GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0043491 [protein kinase B signaling] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045444 [fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046326 [positive regulation of glucose import] GO:0050927 [positive regulation of positive chemotaxis] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0065002 [intracellular protein transmembrane transport] GO:0071156 [regulation of cell cycle arrest] GO:0071407 [cellular response to organic cyclic compound] GO:0072659 [protein localization to plasma membrane] GO:0090314 [positive regulation of protein targeting to membrane] GO:0090630 [activation of GTPase activity] GO:2000147 [positive regulation of cell motility] GO:2001275 [positive regulation of glucose import in response to insulin stimulus]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
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GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0030334 [regulation of cell migration] GO:0031340 [positive regulation of vesicle fusion] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032587 [ruffle membrane] GO:0032869 [cellular response to insulin stimulus] GO:0045444 [fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0046326 [positive regulation of glucose import] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0065002 [intracellular protein transmembrane transport] GO:0071156 [regulation of cell cycle arrest] GO:0090314 [positive regulation of protein targeting to membrane] GO:2000147 [positive regulation of cell motility]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005938 [cell cortex] GO:0005978 [glycogen biosynthetic process] GO:0006006 [glucose metabolic process] GO:0006417 [regulation of translation] GO:0006464 [cellular protein modification process] GO:0006468 [protein phosphorylation] GO:0007165 [signal transduction] GO:0008286 [insulin receptor signaling pathway] GO:0008643 [carbohydrate transport] GO:0010748 [negative regulation of plasma membrane long-chain fatty acid transport] GO:0010907 [positive regulation of glucose metabolic process] GO:0030334 [regulation of cell migration] GO:0031340 [positive regulation of vesicle fusion] GO:0032000 [positive regulation of fatty acid beta-oxidation] GO:0032587 [ruffle membrane] GO:0032869 [cellular response to insulin stimulus] GO:0045444 [fat cell differentiation] GO:0045725 [positive regulation of glycogen biosynthetic process] GO:0046326 [positive regulation of glucose import] GO:0060644 [mammary gland epithelial cell differentiation] GO:0061024 [membrane organization] GO:0065002 [intracellular protein transmembrane transport] GO:0071156 [regulation of cell cycle arrest] GO:0090314 [positive regulation of protein targeting to membrane] GO:2000147 [positive regulation of cell motility]