Tissue expression of PLD3 - Summary - The Human Protein Atlas

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PLD3

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	PLD3
Gene description	Phospholipase D family, member 3
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression at variable levels in most cell types, most abundant in neuronal cells and in immune cells.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending retesting.
Reliability score	Approved based on 2 antibodies. HPA012800 , CAB020812
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	PLD3 (HGNC Symbol)
Synonyms	HU-K4
Description	Phospholipase D family, member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	40348456 - 40380439
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105223 (version 83.38)
Entrez gene	23646
UniProt	Q8IV08 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IV08
Antibodypedia	PLD3 antibodies

PROTEIN BROWSER

PLD3-001	PLD3-002	PLD3-003	PLD3-004	PLD3-006	PLD3-007	PLD3-012	PLD3-017	PLD3-018	PLD3-019	PLD3-020	PLD3-022	PLD3-023	PLD3-025

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLD3-001 ENSP00000386293 ENST00000409419	Q8IV08 [Direct mapping] Phospholipase D3 A0A024R0Q4 [Target identity:100%; Query identity:100%] Phospholipase D family, member 3, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004630 [phospholipase D activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006655 [phosphatidylglycerol biosynthetic process] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0070062 [extracellular exosome] GO:0070290 [N-acylphosphatidylethanolamine-specific phospholipase D activity] Show all	490 aa 54.7 kDa	No	1
PLD3-002 ENSP00000386938 ENST00000409735	Q8IV08 [Direct mapping] Phospholipase D3 A0A024R0Q4 [Target identity:100%; Query identity:100%] Phospholipase D family, member 3, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004630 [phospholipase D activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006655 [phosphatidylglycerol biosynthetic process] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0070062 [extracellular exosome] GO:0070290 [N-acylphosphatidylethanolamine-specific phospholipase D activity] Show all	490 aa 54.7 kDa	No	1
PLD3-003 ENSP00000387050 ENST00000409587	Q8IV08 [Direct mapping] Phospholipase D3 A0A024R0Q4 [Target identity:100%; Query identity:100%] Phospholipase D family, member 3, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004630 [phospholipase D activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006655 [phosphatidylglycerol biosynthetic process] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0070062 [extracellular exosome] GO:0070290 [N-acylphosphatidylethanolamine-specific phospholipase D activity] Show all	490 aa 54.7 kDa	No	1
PLD3-004 ENSP00000348901 ENST00000356508	Q8IV08 [Direct mapping] Phospholipase D3 A0A024R0Q4 [Target identity:100%; Query identity:100%] Phospholipase D family, member 3, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004630 [phospholipase D activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006655 [phosphatidylglycerol biosynthetic process] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0070062 [extracellular exosome] GO:0070290 [N-acylphosphatidylethanolamine-specific phospholipase D activity] Show all	490 aa 54.7 kDa	No	1
PLD3-006 ENSP00000387022 ENST00000409281	Q8IV08 [Direct mapping] Phospholipase D3 A0A024R0Q4 [Target identity:100%; Query identity:100%] Phospholipase D family, member 3, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004630 [phospholipase D activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006655 [phosphatidylglycerol biosynthetic process] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0070062 [extracellular exosome] GO:0070290 [N-acylphosphatidylethanolamine-specific phospholipase D activity] Show all	490 aa 54.7 kDa	No	1
PLD3-007 ENSP00000375886 ENST00000392032	A0A0A0MS28 [Direct mapping] Phospholipase D3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	129 aa 14.3 kDa	No	1
PLD3-012 ENSP00000352220 ENST00000359274	E2QRG1 [Direct mapping] Phospholipase D3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	177 aa 19.4 kDa	No	1
PLD3-017 ENSP00000472854 ENST00000599353	M0R2W7 [Direct mapping] Phospholipase D3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0008152 [metabolic process] Show all	111 aa 12.2 kDa	No	0
PLD3-018 ENSP00000469675 ENST00000599685	M0QY94 [Direct mapping] Phospholipase D3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	70 aa 8 kDa	No	1
PLD3-019 ENSP00000468999 ENST00000602131	M0QX99 [Direct mapping] Phospholipase D3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	120 aa 13.2 kDa	No	1
PLD3-020 ENSP00000468898 ENST00000596682	M0QX50 [Direct mapping] Phospholipase D3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	81 aa 9.3 kDa	No	1
PLD3-022 ENSP00000470603 ENST00000598962	M0QZK2 [Direct mapping] Phospholipase D3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		28 aa 3.2 kDa	No	0
PLD3-023 ENSP00000471838 ENST00000594908	M0R1F7 [Direct mapping] Phospholipase D3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	214 aa 23.7 kDa	No	1
PLD3-025 ENSP00000472509 ENST00000600948	M0R2E7 [Direct mapping] Phospholipase D3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		44 aa 5.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.