Expression of APLP1 in cancer - Summary

CANCER ATLAS

Gene description

Amyloid beta (A4) precursor-like protein 1

Protein class

Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA028970	HPA028971

GENE INFORMATION
Gene name	APLP1 (HGNC Symbol)
Synonyms	APLP
Description	Amyloid beta (A4) precursor-like protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35867899 - 35879791
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105290 (version 83.38)
Entrez gene	333
UniProt	P51693 (UniProt - Evidence at protein level)
neXtProt	NX_P51693
Antibodypedia	APLP1 antibodies

PROTEIN BROWSER

APLP1-001	APLP1-002	APLP1-003	APLP1-005	APLP1-008	APLP1-009	APLP1-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APLP1-001 ENSP00000441501 ENST00000537454	F5GZ08 [Direct mapping] Amyloid-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008201 [heparin binding] GO:0016021 [integral component of membrane] GO:0046914 [transition metal ion binding] Show all	611 aa 68.5 kDa	No	1
APLP1-002 ENSP00000221891 ENST00000221891	P51693 [Direct mapping] Amyloid-like protein 1 C30 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005604 [basement membrane] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0006915 [apoptotic process] GO:0007155 [cell adhesion] GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway] GO:0007399 [nervous system development] GO:0008201 [heparin binding] GO:0009887 [organ morphogenesis] GO:0016021 [integral component of membrane] GO:0030818 [negative regulation of cAMP biosynthetic process] GO:0031694 [alpha-2A adrenergic receptor binding] GO:0031695 [alpha-2B adrenergic receptor binding] GO:0031696 [alpha-2C adrenergic receptor binding] GO:0042802 [identical protein binding] GO:0046914 [transition metal ion binding] GO:0048471 [perinuclear region of cytoplasm] GO:0071874 [cellular response to norepinephrine stimulus] Show all	651 aa 72.2 kDa	Yes	1
APLP1-003 ENSP00000465694 ENST00000586861	B7Z4G8 [Direct mapping] Amyloid-like protein 1; cDNA FLJ56046, highly similar to Amyloid-like protein 1 (APLP)(APLP-1) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008201 [heparin binding] GO:0016021 [integral component of membrane] GO:0046914 [transition metal ion binding] Show all	644 aa 71.7 kDa	No	1
APLP1-005 ENSP00000466576 ENST00000588808	K7EMN4 [Direct mapping] Amyloid-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	222 aa 24.5 kDa	No	1
APLP1-008 ENSP00000466116 ENST00000589743	K7ELK0 [Direct mapping] Amyloid-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008201 [heparin binding] GO:0046914 [transition metal ion binding] Show all	173 aa 19.1 kDa	No	0
APLP1-009 ENSP00000474762 ENST00000587274	S4R3U6 [Direct mapping] Amyloid-like protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	289 aa 32.3 kDa	No	1
APLP1-011 ENSP00000467854 ENST00000592316	K7EQJ4 [Direct mapping] Amyloid-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008201 [heparin binding] GO:0016021 [integral component of membrane] GO:0046914 [transition metal ion binding] Show all	294 aa 32.9 kDa	No	0