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BBC3

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GENERAL INFORMATION

Gene name

 BBC3

Gene description

 BCL2 binding component 3

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA070403
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA070403 Hep G2 Cytosol
HPA070403 SK-MEL-30 Cytosol
HPA070403 U-2 OS Cytosol

GENE INFORMATION

Gene name

 BBC3 (HGNC Symbol)

Synonyms

 JFY1, PUMA

Description

 BCL2 binding component 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 47220822 - 47232766

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105327 (version 83.38)

Entrez gene

 27113

UniProt

 Q96PG8 (UniProt - Evidence at transcript level), Q9BXH1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96PG8, NX_Q9BXH1

Antibodypedia

 BBC3 antibodies

PROTEIN BROWSER
BBC3-001
BBC3-002
BBC3-003
BBC3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BBC3-001
ENSP00000404503
ENST00000449228
Q96PG8 [Direct mapping]
Bcl-2-binding component 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0006915 [apoptotic process]
GO:0051117 [ATPase binding]
Show all
 261 aa
26.5 kDa 		No 0
BBC3-002
ENSP00000341155
ENST00000341983
Q9BXH1 [Direct mapping]
Bcl-2-binding component 3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008340 [determination of adult lifespan]
GO:0012501 [programmed cell death]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045926 [negative regulation of growth]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071456 [cellular response to hypoxia]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097190 [apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 131 aa
14.5 kDa 		No 0
BBC3-003
ENSP00000395862
ENST00000439096
Q9BXH1 [Direct mapping]
Bcl-2-binding component 3
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001836 [release of cytochrome c from mitochondria]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005741 [mitochondrial outer membrane]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0008340 [determination of adult lifespan]
GO:0012501 [programmed cell death]
GO:0032464 [positive regulation of protein homooligomerization]
GO:0032471 [negative regulation of endoplasmic reticulum calcium ion concentration]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0045926 [negative regulation of growth]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071456 [cellular response to hypoxia]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0097190 [apoptotic signaling pathway]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097194 [execution phase of apoptosis]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903896 [positive regulation of IRE1-mediated unfolded protein response]
GO:2001056 [positive regulation of cysteine-type endopeptidase activity]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 193 aa
20.5 kDa 		No 0
BBC3-005
ENSP00000300880
ENST00000300880
Q96PG8 [Direct mapping]
Bcl-2-binding component 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0006915 [apoptotic process]
GO:0051117 [ATPase binding]
Show all
 101 aa
10.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.