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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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PLIN3
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

PLIN3

Gene description

Perilipin 3

Protein class

FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several different tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Uncertain based on 2 antibodies.
HPA006427 , HPA066538
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Nasopharynx

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080100120TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin010203040506070RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina020406080100Tags Per Million

GENE INFORMATION

Gene name

PLIN3 (HGNC Symbol)

Synonyms

M6PRBP1, PP17, TIP47

Description

Perilipin 3 (HGNC Symbol)

Entrez gene summary

Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

4838341 - 4867768

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105355 (version 83.38)

Entrez gene

10226

UniProt

O60664 (UniProt - Evidence at protein level)

neXtProt

NX_O60664

Antibodypedia

PLIN3 antibodies

PROTEIN BROWSER

PLIN3-001
PLIN3-002
PLIN3-003
PLIN3-004
PLIN3-005
PLIN3-007
PLIN3-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PLIN3-001
ENSP00000221957
ENST00000221957
O60664 [Direct mapping]
Perilipin-3
Show all
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid particle]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
434 aa
47.1 kDa
No 0
PLIN3-002
ENSP00000468096
ENST00000589494
K7ER39 [Direct mapping]
Perilipin-3
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
168 aa
17.6 kDa
No 0
PLIN3-003
ENSP00000465117
ENST00000587462
K7EJD0 [Direct mapping]
Perilipin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
35 aa
3.6 kDa
No 0
PLIN3-004
ENSP00000465975
ENST00000589034
K7EL96 [Direct mapping]
Perilipin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
173 aa
18.1 kDa
No 0
PLIN3-005
ENSP00000468476
ENST00000589163
K7ERZ3 [Direct mapping]
Perilipin-3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
292 aa
31.9 kDa
No 0
PLIN3-007
ENSP00000467803
ENST00000592528
O60664 [Direct mapping]
Perilipin-3
Show all
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid particle]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
422 aa
45.8 kDa
No 0
PLIN3-008
ENSP00000465596
ENST00000585479
O60664 [Direct mapping]
Perilipin-3
Show all
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0005811 [lipid particle]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016192 [vesicle-mediated transport]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
433 aa
46.9 kDa
No 0

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The Human Protein Atlas project is funded
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