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RPS19

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GENERAL INFORMATION

Gene name

 RPS19

Gene description

 Ribosomal protein S19

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 RPS19 (HGNC Symbol)

Synonyms

 DBA, S19

Description

 Ribosomal protein S19 (HGNC Symbol)

Entrez gene summary

 Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 41859918 - 41872926

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105372 (version 83.38)

Entrez gene

 6223

UniProt

 P39019 (UniProt - Evidence at protein level)

neXtProt

 NX_P39019

Antibodypedia

 RPS19 antibodies

PROTEIN BROWSER
RPS19-001
RPS19-002
RPS19-003
RPS19-005
RPS19-006
RPS19-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPS19-001
ENSP00000470972
ENST00000598742
P39019 [Direct mapping]
40S ribosomal protein S19
B0ZBD0 [Target identity:100%; Query identity:100%]
40S ribosomal protein S19; Ribosomal protein S19, isoform CRA_a; cDNA, FLJ92047, Homo sapiens ribosomal protein S19 (RPS19), mRNA
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000028 [ribosomal small subunit assembly]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0002548 [monocyte chemotaxis]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005925 [focal adhesion]
GO:0006364 [rRNA processing]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0007000 [nucleolus organization]
GO:0007219 [Notch signaling pathway]
GO:0009991 [response to extracellular stimulus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0017134 [fibroblast growth factor binding]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019901 [protein kinase binding]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030218 [erythrocyte differentiation]
GO:0030490 [maturation of SSU-rRNA]
GO:0042274 [ribosomal small subunit biogenesis]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0051262 [protein tetramerization]
GO:0051272 [positive regulation of cellular component movement]
GO:0060265 [positive regulation of respiratory burst involved in inflammatory response]
GO:0060266 [negative regulation of respiratory burst involved in inflammatory response]
GO:0070062 [extracellular exosome]
Show all
 145 aa
16.1 kDa 		No 0
RPS19-002
ENSP00000469228
ENST00000600467
M0QXK4 [Direct mapping]
40S ribosomal protein S19
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 76 aa
8.5 kDa 		No 0
RPS19-003
ENSP00000471621
ENST00000601492
M0R140 [Direct mapping]
40S ribosomal protein S19
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 102 aa
11.1 kDa 		No 0
RPS19-005
ENSP00000221975
ENST00000221975
A0A075B6E2 [Direct mapping]
40S ribosomal protein S19
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 71 aa
7.8 kDa 		No 0
RPS19-006
ENSP00000470004
ENST00000593863
P39019 [Direct mapping]
40S ribosomal protein S19
B0ZBD0 [Target identity:100%; Query identity:100%]
40S ribosomal protein S19; Ribosomal protein S19, isoform CRA_a; cDNA, FLJ92047, Homo sapiens ribosomal protein S19 (RPS19), mRNA
Show all
Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000028 [ribosomal small subunit assembly]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000462 [maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0002548 [monocyte chemotaxis]
GO:0003735 [structural constituent of ribosome]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005925 [focal adhesion]
GO:0006364 [rRNA processing]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0007000 [nucleolus organization]
GO:0009991 [response to extracellular stimulus]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0017134 [fibroblast growth factor binding]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0019901 [protein kinase binding]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030218 [erythrocyte differentiation]
GO:0030490 [maturation of SSU-rRNA]
GO:0042274 [ribosomal small subunit biogenesis]
GO:0042803 [protein homodimerization activity]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0051262 [protein tetramerization]
GO:0051272 [positive regulation of cellular component movement]
GO:0060265 [positive regulation of respiratory burst involved in inflammatory response]
GO:0060266 [negative regulation of respiratory burst involved in inflammatory response]
GO:0070062 [extracellular exosome]
Show all
 145 aa
16.1 kDa 		No 0
RPS19-007
ENSP00000469798
ENST00000598261
M0QYF7 [Direct mapping]
40S ribosomal protein S19
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003735 [structural constituent of ribosome]
GO:0005840 [ribosome]
GO:0006412 [translation]
Show all
 100 aa
11.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.