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CRX

GENERAL INFORMATION

Gene name

 CRX

Gene description

 Cone-rod homeobox

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Not detected
GTEx:Not detected
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear expression in photoreceptor cells in retina.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 2 antibodies.
HPA036762 , HPA036763
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

 CRX (HGNC Symbol)

Synonyms

 CORD2, CRD, LCA7, OTX3

Description

 Cone-rod homeobox (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 47819779 - 47843330

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105392 (version 83.38)

Entrez gene

 1406

UniProt

 O43186 (UniProt - Evidence at protein level)

neXtProt

 NX_O43186

Antibodypedia

 CRX antibodies

PROTEIN BROWSER
CRX-001
CRX-005
CRX-008
CRX-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CRX-001
ENSP00000221996
ENST00000221996
O43186 [Direct mapping]
Cone-rod homeobox protein
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Kim et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007601 [visual perception]
GO:0007623 [circadian rhythm]
GO:0009887 [organ morphogenesis]
GO:0035257 [nuclear hormone receptor binding]
GO:0043522 [leucine zipper domain binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046534 [positive regulation of photoreceptor cell differentiation]
GO:0050896 [response to stimulus]
GO:0060041 [retina development in camera-type eye]
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 299 aa
32.3 kDa 		No 0
CRX-005
ENSP00000457808
ENST00000566686
H3BUU7 [Direct mapping]
Cone-rod homeobox protein
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
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 57 aa
6.4 kDa 		No 0
CRX-008
ENSP00000478106
ENST00000613299
A0A087WTS9 [Direct mapping]
Cone-rod homeobox protein
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Predicted intracellular proteins
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 41 aa
4.4 kDa 		No 0
CRX-201
ENSP00000445565
ENST00000539067
O43186 [Direct mapping]
Cone-rod homeobox protein
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0007601 [visual perception]
GO:0009887 [organ morphogenesis]
GO:0035257 [nuclear hormone receptor binding]
GO:0043522 [leucine zipper domain binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050896 [response to stimulus]
Show all
 299 aa
32.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.