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The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006457 [protein folding] GO:0006605 [protein targeting] GO:0010608 [posttranscriptional regulation of gene expression] GO:0019887 [protein kinase regulator activity] GO:0019900 [kinase binding] GO:0019901 [protein kinase binding] GO:0031072 [heat shock protein binding] GO:0045859 [regulation of protein kinase activity] GO:0050821 [protein stabilization] GO:0051082 [unfolded protein binding] GO:0051087 [chaperone binding] GO:0051879 [Hsp90 protein binding] GO:0060334 [regulation of interferon-gamma-mediated signaling pathway] GO:0060338 [regulation of type I interferon-mediated signaling pathway] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] GO:1990565 [HSP90-CDC37 chaperone complex]
