Cell atlas - MEIS3 - The Human Protein Atlas

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MEIS3

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MEIS3
Gene description	Meis homeobox 3
Protein class	Predicted intracellular proteins Predicted secreted proteins Transcription factors
Predicted localization	Intracellular,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (AF22)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA046699
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA046699	A549	Nucleoplasm
	HPA046699	MCF7	Nucleoplasm
	HPA046699	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	MEIS3 (HGNC Symbol)
Synonyms	DKFZp547H236, MRG2
Description	Meis homeobox 3 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.32
Chromosome location (bp)	47403124 - 47419523
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105419 (version 83.38)
Entrez gene	56917
UniProt	Q99687 (UniProt - Evidence at transcript level)
neXtProt	NX_Q99687
Antibodypedia	MEIS3 antibodies

PROTEIN BROWSER

MEIS3-001	MEIS3-002	MEIS3-003	MEIS3-005	MEIS3-007	MEIS3-008	MEIS3-011	MEIS3-013	MEIS3-014	MEIS3-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MEIS3-001 ENSP00000333552 ENST00000331559	H3BLU4 [Direct mapping] Homeobox protein Meis3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	404 aa 44.1 kDa	No	0
MEIS3-002 ENSP00000388667 ENST00000441740	Q99687 [Direct mapping] Homeobox protein Meis3 A0A024R0S2 [Target identity:100%; Query identity:100%] Meis1, myeloid ecotropic viral integration site 1 homolog 3 (Mouse), isoform CRA_b Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	358 aa 39.1 kDa	No	0
MEIS3-003 ENSP00000452854 ENST00000559524	Q99687 [Direct mapping] Homeobox protein Meis3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	421 aa 46.2 kDa	No	0
MEIS3-005 ENSP00000454073 ENST00000558555	Q99687 [Direct mapping] Homeobox protein Meis3 A0A024R0W2 [Target identity:100%; Query identity:100%] Meis1, myeloid ecotropic viral integration site 1 homolog 3 (Mouse), isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding] Show all	375 aa 41.1 kDa	No	0
MEIS3-007 ENSP00000453307 ENST00000561293	Q99687 [Direct mapping] Homeobox protein Meis3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051897 [positive regulation of protein kinase B signaling] GO:2001234 [negative regulation of apoptotic signaling pathway] Show all	421 aa 46.2 kDa	No	0
MEIS3-008 ENSP00000453757 ENST00000560245	H0YMV2 [Direct mapping] Homeobox protein Meis3 Q59FK5 [Target identity:100%; Query identity:100%] Homeobox protein Meis3 variant Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	250 aa 27.4 kDa	No	0
MEIS3-011 ENSP00000453934 ENST00000561096	H0YNA8 [Direct mapping] Homeobox protein Meis3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	463 aa 50.3 kDa	Yes	0
MEIS3-013 ENSP00000476248 ENST00000557833	U3KQV2 [Direct mapping] Homeobox protein Meis3 Show all	Predicted intracellular proteins Show all		221 aa 23.4 kDa	No	0
MEIS3-014 ENSP00000453249 ENST00000559338	H0YLL0 [Direct mapping] Homeobox protein Meis3 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] Show all	178 aa 19.1 kDa	No	0
MEIS3-016 ENSP00000475941 ENST00000607695	U3KQJ9 [Direct mapping] Homeobox protein Meis3 Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	126 aa 14.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.