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Hepatocellular carcinomas showed moderate to strong cytoplasmic staining. Few cases of duct carcinomas of breast, papillary adenocarcinomas of thyroid, colorectal, lung, renal and pancreatic cancers exhibited moderate positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
MEGF8 (HGNC Symbol)
Synonyms
C19orf49, EGFL4, FLJ22365, SBP1
Description
Multiple EGF-like-domains 8 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]