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The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0030155 [regulation of cell adhesion] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0030155 [regulation of cell adhesion] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity]
Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity] GO:0030155 [regulation of cell adhesion] GO:0032012 [regulation of ARF protein signal transduction] GO:0043547 [positive regulation of GTPase activity]
