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Most cancers showed moderate to strong cytoplasmic and/or nuclear immunoreactivity. Additional membranous positivity was observed in colorectal cancers.
Cancers showed moderate nuclear and occasional cytoplasmic positivity. Many cases of testicular and skin cancers along with a few cases of melanomas, urothelial and gastric cancers showed strong staining.
GENE INFORMATION
Gene name
CARD8 (HGNC Symbol)
Synonyms
CARDINAL, Dakar, KIAA0955, NDPP, TUCAN
Description
Caspase recruitment domain family, member 8 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]