Expression of SIGLEC5 in cancer - Summary

CANCER ATLAS

Gene description

Sialic acid binding Ig-like lectin 5

Protein class

CD markers, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA009085	CAB024900

GENE INFORMATION
Gene name	SIGLEC5 (HGNC Symbol)
Synonyms	CD170, CD33L2, OB-BP2, SIGLEC-5
Description	Sialic acid binding Ig-like lectin 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	51611503 - 51645545
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105501 (version 83.38)
Entrez gene	8778
UniProt	O15389 (UniProt - Evidence at protein level)
neXtProt	NX_O15389
Antibodypedia	SIGLEC5 antibodies

PROTEIN BROWSER

SIGLEC5-001	SIGLEC5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIGLEC5-001 ENSP00000473238 ENST00000534261	O15389 [Direct mapping] Sialic acid-binding Ig-like lectin 5 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	551 aa 60.7 kDa	Yes	1
SIGLEC5-201 ENSP00000455510 ENST00000570106	O15389 [Direct mapping] Sialic acid-binding Ig-like lectin 5 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] Show all	551 aa 60.7 kDa	Yes	1