Expression of HAS1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Hyaluronan synthase 1

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

HPA067602

GENE INFORMATION
Gene name	HAS1 (HGNC Symbol)
Synonyms	HAS
Description	Hyaluronan synthase 1 (HGNC Symbol)
Entrez gene summary	Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	51713112 - 51723994
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105509 (version 83.38)
Entrez gene	3036
UniProt	Q92839 (UniProt - Evidence at protein level)
neXtProt	NX_Q92839
Antibodypedia	HAS1 antibodies

PROTEIN BROWSER

HAS1-001	HAS1-002	HAS1-003	HAS1-004	HAS1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAS1-001 ENSP00000445021 ENST00000540069	G3V1S7 [Direct mapping] Hyaluronan synthase 1; Hyaluronan synthase 1, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030213 [hyaluronan biosynthetic process] GO:0045226 [extracellular polysaccharide biosynthetic process] GO:0050501 [hyaluronan synthase activity] GO:0085029 [extracellular matrix assembly] Show all	577 aa 64.7 kDa	No	7
HAS1-002 ENSP00000472821 ENST00000601714	M0R2V0 [Direct mapping] Hyaluronan synthase 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] GO:0030213 [hyaluronan biosynthetic process] GO:0045226 [extracellular polysaccharide biosynthetic process] GO:0050501 [hyaluronan synthase activity] GO:0085029 [extracellular matrix assembly] Show all	585 aa 65.6 kDa	No	7
HAS1-003 ENSP00000469165 ENST00000594621	M0QXH4 [Direct mapping] Hyaluronan synthase 1 Show all	Predicted intracellular proteins Show all	GO:0030213 [hyaluronan biosynthetic process] GO:0045226 [extracellular polysaccharide biosynthetic process] GO:0050501 [hyaluronan synthase activity] GO:0085029 [extracellular matrix assembly] Show all	214 aa 23.6 kDa	No	0
HAS1-004 ENSP00000471953 ENST00000601667	M0R1L3 [Direct mapping] Hyaluronan synthase 1 Show all	Predicted intracellular proteins Show all	GO:0030213 [hyaluronan biosynthetic process] GO:0045226 [extracellular polysaccharide biosynthetic process] GO:0050501 [hyaluronan synthase activity] GO:0085029 [extracellular matrix assembly] Show all	140 aa 15.9 kDa	No	0
HAS1-005 ENSP00000222115 ENST00000222115	Q92839 [Direct mapping] Hyaluronan synthase 1 Show all	Enzymes ENZYME proteins Transferases Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0007155 [cell adhesion] GO:0010764 [negative regulation of fibroblast migration] GO:0016020 [membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030212 [hyaluronan metabolic process] GO:0030213 [hyaluronan biosynthetic process] GO:0036120 [cellular response to platelet-derived growth factor stimulus] GO:0044281 [small molecule metabolic process] GO:0044849 [estrous cycle] GO:0045226 [extracellular polysaccharide biosynthetic process] GO:0050501 [hyaluronan synthase activity] GO:0085029 [extracellular matrix assembly] Show all	578 aa 64.8 kDa	No	7