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Term
Gene name

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Chromosome

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Validation

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Method

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Searches

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Detectable

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Antibodies

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HAS1
  • TISSUE

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CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Hyaluronan synthase 1

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA067602

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of duct carcinomas of breast, head and neck cancers along with lung, skin and ovarian cancers displayed weak to moderate nucleolar staining and occasional cytoplasmic positivity. Several cases of melanomas, ovarian, testis, thyroid and urothelial cancers showed weak to moderate nucleolar immunoreactivity. Remaining cancer tissues were mainly negative.

GENE INFORMATION

Gene name

HAS1 (HGNC Symbol)

Synonyms

HAS

Description

Hyaluronan synthase 1 (HGNC Symbol)

Entrez gene summary

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Chromosome

19

Cytoband

q13.41

Chromosome location (bp)

51713112 - 51723994

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000105509 (version 83.38)

Entrez gene

3036

UniProt

Q92839 (UniProt - Evidence at protein level)

neXtProt

NX_Q92839

Antibodypedia

HAS1 antibodies

PROTEIN BROWSER

HAS1-001
HAS1-002
HAS1-003
HAS1-004
HAS1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HAS1-001
ENSP00000445021
ENST00000540069
G3V1S7 [Direct mapping]
Hyaluronan synthase 1; Hyaluronan synthase 1, isoform CRA_b
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
GO:0030213 [hyaluronan biosynthetic process]
GO:0045226 [extracellular polysaccharide biosynthetic process]
GO:0050501 [hyaluronan synthase activity]
GO:0085029 [extracellular matrix assembly]
Show all
577 aa
64.7 kDa
No 7
HAS1-002
ENSP00000472821
ENST00000601714
M0R2V0 [Direct mapping]
Hyaluronan synthase 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0016021 [integral component of membrane]
GO:0030213 [hyaluronan biosynthetic process]
GO:0045226 [extracellular polysaccharide biosynthetic process]
GO:0050501 [hyaluronan synthase activity]
GO:0085029 [extracellular matrix assembly]
Show all
585 aa
65.6 kDa
No 7
HAS1-003
ENSP00000469165
ENST00000594621
M0QXH4 [Direct mapping]
Hyaluronan synthase 1
Show all
Predicted intracellular proteins
Show all
GO:0030213 [hyaluronan biosynthetic process]
GO:0045226 [extracellular polysaccharide biosynthetic process]
GO:0050501 [hyaluronan synthase activity]
GO:0085029 [extracellular matrix assembly]
Show all
214 aa
23.6 kDa
No 0
HAS1-004
ENSP00000471953
ENST00000601667
M0R1L3 [Direct mapping]
Hyaluronan synthase 1
Show all
Predicted intracellular proteins
Show all
GO:0030213 [hyaluronan biosynthetic process]
GO:0045226 [extracellular polysaccharide biosynthetic process]
GO:0050501 [hyaluronan synthase activity]
GO:0085029 [extracellular matrix assembly]
Show all
140 aa
15.9 kDa
No 0
HAS1-005
ENSP00000222115
ENST00000222115
Q92839 [Direct mapping]
Hyaluronan synthase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006024 [glycosaminoglycan biosynthetic process]
GO:0007155 [cell adhesion]
GO:0010764 [negative regulation of fibroblast migration]
GO:0016020 [membrane]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0030212 [hyaluronan metabolic process]
GO:0030213 [hyaluronan biosynthetic process]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0044281 [small molecule metabolic process]
GO:0044849 [estrous cycle]
GO:0045226 [extracellular polysaccharide biosynthetic process]
GO:0050501 [hyaluronan synthase activity]
GO:0085029 [extracellular matrix assembly]
Show all
578 aa
64.8 kDa
No 7

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